Matches in DBpedia 2014 for { <http://dbpedia.org/resource/CcdA/CcdB_Type_II_Toxin-antitoxin_system> ?p ?o. }
Showing items 1 to 32 of
32
with 100 items per page.
- CcdB_Type_II_Toxin-antitoxin_system abstract "The CcdA/CCdB Type II Toxin-antitoxin system is one example of the bacterial toxin-antitoxin (TA) systems that encode two proteins, one a potent inhibitor of cell proliferation (toxin) and the other its specific antidote (antitoxin). These systems preferentially guarantee growth of plasmid-carrying daughter cells in a bacterial population by killing newborn bacteria that have not inherited a plasmid copy at cell division (post-segregational killing).The ccd system (control of cell death) of the F plasmid encodes two proteins, the CcdB toxin (101 amino acids) and the CcdA antidote (72 amino acids). The antidote or antitoxin prevents CcdB toxicity by forming a tight CcdA–CcdB complex. The target of CcdB is the GyrA subunit of DNA gyrase, an essential type II topoisomerase in Escherichia coli.CcdB protein is a topoisomerase poison from Escherichia coli. It is responsible for killing plasmid-free segregants, and interferes with the activity of DNA gyrase. It acts to inhibit partitioning of the chromosomal DNA.Regulation of the ccd operon by the CCdA/CCdB complex is dependent upon the ratio of the two molecules to each other in the complex: a (CcdA)2–(CcdB)2 complex binds the DNA of the operon thus repressing transcription, but when CcdB is in excess of CcdA de-repression occurs, whereas repression will occur when CcdA levels are greater than or equal to that of CcdB. As a model system, by ensuring an antidote–toxin ratio greater than one, this mechanism might prevent the harmful effect of CcdB in plasmid-containing bacteria.The Ccd and parD systems are found to be strikingly similar in terms of their structures and actions. The antitoxin protein of each system interacts with its cognate toxin to neutralise the activity of the toxin and in the process the complex of the two becomes an efficient transcription repressor.".
- CcdB_Type_II_Toxin-antitoxin_system symbol "CcdA".
- CcdB_Type_II_Toxin-antitoxin_system symbol "CcdB".
- CcdB_Type_II_Toxin-antitoxin_system thumbnail PDB_2vub_EBI.jpg?width=300.
- CcdB_Type_II_Toxin-antitoxin_system wikiPageExternalLink index.php.
- CcdB_Type_II_Toxin-antitoxin_system wikiPageID "37411028".
- CcdB_Type_II_Toxin-antitoxin_system wikiPageRevisionID "590870893".
- CcdB_Type_II_Toxin-antitoxin_system caption "ccdb dimer in complex with one c-terminal ccda domain".
- CcdB_Type_II_Toxin-antitoxin_system caption "ccdb, a topoisomerase poison from e. coli".
- CcdB_Type_II_Toxin-antitoxin_system hasPhotoCollection CcdB_Type_II_Toxin-antitoxin_system.
- CcdB_Type_II_Toxin-antitoxin_system interpro "IPR002712".
- CcdB_Type_II_Toxin-antitoxin_system interpro "IPR009956".
- CcdB_Type_II_Toxin-antitoxin_system name "CcdA Antitoxin of Type II Toxin-antitoxin system".
- CcdB_Type_II_Toxin-antitoxin_system name "CcdB Toxin of Type II Toxin-antitoxin system".
- CcdB_Type_II_Toxin-antitoxin_system pfam "PF01845".
- CcdB_Type_II_Toxin-antitoxin_system pfam "PF07362".
- CcdB_Type_II_Toxin-antitoxin_system pfamClan "CL0057".
- CcdB_Type_II_Toxin-antitoxin_system scop "4".
- CcdB_Type_II_Toxin-antitoxin_system symbol "CcdA".
- CcdB_Type_II_Toxin-antitoxin_system symbol "CcdB".
- CcdB_Type_II_Toxin-antitoxin_system subject Category:Protein_families.
- CcdB_Type_II_Toxin-antitoxin_system type Biomolecule.
- CcdB_Type_II_Toxin-antitoxin_system type Protein.
- CcdB_Type_II_Toxin-antitoxin_system type BiologicalObject.
- CcdB_Type_II_Toxin-antitoxin_system comment "The CcdA/CCdB Type II Toxin-antitoxin system is one example of the bacterial toxin-antitoxin (TA) systems that encode two proteins, one a potent inhibitor of cell proliferation (toxin) and the other its specific antidote (antitoxin).".
- CcdB_Type_II_Toxin-antitoxin_system label "CcdA/CcdB Type II Toxin-antitoxin system".
- CcdB_Type_II_Toxin-antitoxin_system sameAs m.0nb8p4s.
- CcdB_Type_II_Toxin-antitoxin_system sameAs Q5055634.
- CcdB_Type_II_Toxin-antitoxin_system sameAs Q5055634.
- CcdB_Type_II_Toxin-antitoxin_system wasDerivedFrom CcdB_Type_II_Toxin-antitoxin_system?oldid=590870893.
- CcdB_Type_II_Toxin-antitoxin_system depiction PDB_2vub_EBI.jpg.
- CcdB_Type_II_Toxin-antitoxin_system isPrimaryTopicOf CcdB_Type_II_Toxin-antitoxin_system.
