Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Ceragenin> ?p ?o. }
Showing items 1 to 31 of
31
with 100 items per page.
- Ceragenin abstract "Ceragenins, or cationic selective antimicrobials (CSAs), are synthetically produced small molecule chemical compounds consisting of a sterol backbone with amino acids and other chemical groups attached to them. These compounds have a net positive charge that is electrostatically attracted to the negatively charged cell membranes of certain viruses, fungi and bacteria. CSAs have a high binding affinity for such membranes (including Lipid A) and are able to rapidly disrupt the target membranes leading to rapid cell death. While CSAs have a mechanism of action that is also seen in antimicrobial peptides, which form part of the body's innate immune system, they avoid many of the difficulties associated with their use as medicines.Ceragenins were invented by Dr. Paul B. Savage of Brigham Young University's Department of Chemistry and Biochemistry and exclusively licensed to Ceragenix. In data previously presented by Dr. Savage and other researchers, CSAs have been shown to have broad spectrum antibacterial activity. Dr. Derya Unutmaz, Associate Professor of Microbiology and Immunology at the Vanderbilt University School of Medicine, tested several CSAs in his laboratory for their ability to kill HIV directly. According to Unutmaz, "We have some preliminary but very exciting results. But we would like to formally show this before making any claims that would cause unwanted hype."On February 6, 2006, researchers (including Dr. Paul B. Savage) announced that a Ceragenin compound, CSA-54, appears to inactivate HIV. This conclusion seems to still be awaiting peer review.".
- Ceragenin thumbnail CSA-8.png?width=300.
- Ceragenin wikiPageExternalLink www.ceragenix.com.
- Ceragenin wikiPageExternalLink bnitem.aspx?name=1160759XSL_NEWSML_TO_NEWSML.xml.
- Ceragenin wikiPageID "4001307".
- Ceragenin wikiPageRevisionID "589039089".
- Ceragenin hasPhotoCollection Ceragenin.
- Ceragenin subject Category:Antibiotics.
- Ceragenin subject Category:Steroids.
- Ceragenin type Abstraction100002137.
- Ceragenin type Chemical114806838.
- Ceragenin type Compound114818238.
- Ceragenin type Material114580897.
- Ceragenin type Matter100020827.
- Ceragenin type OrganicCompound114727670.
- Ceragenin type Part113809207.
- Ceragenin type PhysicalEntity100001930.
- Ceragenin type Relation100031921.
- Ceragenin type Steroid115057744.
- Ceragenin type Steroids.
- Ceragenin type Substance100019613.
- Ceragenin comment "Ceragenins, or cationic selective antimicrobials (CSAs), are synthetically produced small molecule chemical compounds consisting of a sterol backbone with amino acids and other chemical groups attached to them. These compounds have a net positive charge that is electrostatically attracted to the negatively charged cell membranes of certain viruses, fungi and bacteria.".
- Ceragenin label "Ceragenin".
- Ceragenin sameAs m.0bby3q.
- Ceragenin sameAs Q5063611.
- Ceragenin sameAs Q5063611.
- Ceragenin sameAs Ceragenin.
- Ceragenin wasDerivedFrom Ceragenin?oldid=589039089.
- Ceragenin depiction CSA-8.png.
- Ceragenin homepage www.ceragenix.com.
- Ceragenin isPrimaryTopicOf Ceragenin.
