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- Chimerin_2 abstract "Beta-chimaerin is a protein that in humans is encoded by the CHN2 gene.This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.".
- Chimerin_2 entrezgene "1124".
- Chimerin_2 wikiPageID "14775969".
- Chimerin_2 wikiPageRevisionID "593728510".
- Chimerin_2 hasPhotoCollection Chimerin_2.
- Chimerin_2 requireManualInspection "no".
- Chimerin_2 summaryText "This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.".
- Chimerin_2 updateCitations "yes".
- Chimerin_2 updatePage "yes".
- Chimerin_2 updateProteinBox "yes".
- Chimerin_2 updateSummary "yes".
- Chimerin_2 type Biomolecule.
- Chimerin_2 type Protein.
- Chimerin_2 type BiologicalObject.
- Chimerin_2 comment "Beta-chimaerin is a protein that in humans is encoded by the CHN2 gene.This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane.".
- Chimerin_2 label "Chimerin 2".
- Chimerin_2 label "Chimerin 2".
- Chimerin_2 sameAs Chimerin_2.
- Chimerin_2 sameAs m.03gxmp4.
- Chimerin_2 sameAs Q5099366.
- Chimerin_2 sameAs Q5099366.
- Chimerin_2 wasDerivedFrom Chimerin_2?oldid=593728510.
- Chimerin_2 isPrimaryTopicOf Chimerin_2.