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- Chloramphenicol_acetyltransferase abstract "Chloramphenicol acetyltransferase (or CAT) is a bacterial enzyme (EC 2.3.1.28) that detoxifies the antibiotic chloramphenicol and is responsible for chloramphenicol resistance in bacteria. This enzyme covalently attaches an acetyl group from acetyl-CoA to chloramphenicol, which prevents chloramphenicol from binding to ribosomes. A histidine residue, located in the C-terminal section of the enzyme, plays a central role in its catalytic mechanism.The crystal structure of the type III enzyme from Escherichia coli with chloramphenicol bound has been determined. CAT is a trimer of identical subunits (monomer Mr 25,000) and the trimeric structure is stabilised by a number of hydrogen bonds, some of which result in the extension of a beta-sheet across the subunit interface. Chloramphenicol binds in a deep pocket located at the boundary between adjacent subunits of the trimer, such that the majority of residues forming the binding pocket belong to one subunit while the catalytically essential histidine belongs to the adjacent subunit. His195 is appropriately positioned to act as a general base catalyst in the reaction, and the required tautomeric stabilisation is provided by an unusual interaction with a main-chain carbonyl oxygen.".
- Chloramphenicol_acetyltransferase symbol "CAT".
- Chloramphenicol_acetyltransferase thumbnail Chloramphenicol_acetyltransferase_3CLA_transparent.png?width=300.
- Chloramphenicol_acetyltransferase wikiPageID "2440667".
- Chloramphenicol_acetyltransferase wikiPageRevisionID "584887974".
- Chloramphenicol_acetyltransferase caption "Ribbon diagram of the chloramphenicol acetyltransferase trimer with chloramphenicol bound. From .".
- Chloramphenicol_acetyltransferase casNumber "9040-07-07".
- Chloramphenicol_acetyltransferase ecNumber "2.3".
- Chloramphenicol_acetyltransferase goCode "16740".
- Chloramphenicol_acetyltransferase hasPhotoCollection Chloramphenicol_acetyltransferase.
- Chloramphenicol_acetyltransferase interpro "IPR001707".
- Chloramphenicol_acetyltransferase name "Chloramphenicol acetyltransferase".
- Chloramphenicol_acetyltransferase pdb "G:6-209 A:6-209 B:6-209 :1-205 :1-205 :1-205 :1-205 :1-205 :1-205".
- Chloramphenicol_acetyltransferase pfam "PF00302".
- Chloramphenicol_acetyltransferase prosite "PDOC00093".
- Chloramphenicol_acetyltransferase scop "3".
- Chloramphenicol_acetyltransferase symbol "CAT".
- Chloramphenicol_acetyltransferase subject Category:Bacterial_enzymes.
- Chloramphenicol_acetyltransferase subject Category:EC_2.3.1.
- Chloramphenicol_acetyltransferase type Abstraction100002137.
- Chloramphenicol_acetyltransferase type Activator114723079.
- Chloramphenicol_acetyltransferase type BacterialEnzymes.
- Chloramphenicol_acetyltransferase type Catalyst114723628.
- Chloramphenicol_acetyltransferase type Chemical114806838.
- Chloramphenicol_acetyltransferase type Compound114818238.
- Chloramphenicol_acetyltransferase type Enzyme114732946.
- Chloramphenicol_acetyltransferase type Macromolecule114944888.
- Chloramphenicol_acetyltransferase type Material114580897.
- Chloramphenicol_acetyltransferase type Matter100020827.
- Chloramphenicol_acetyltransferase type Molecule114682133.
- Chloramphenicol_acetyltransferase type OrganicCompound114727670.
- Chloramphenicol_acetyltransferase type Part113809207.
- Chloramphenicol_acetyltransferase type PhysicalEntity100001930.
- Chloramphenicol_acetyltransferase type Protein114728724.
- Chloramphenicol_acetyltransferase type Relation100031921.
- Chloramphenicol_acetyltransferase type Substance100019613.
- Chloramphenicol_acetyltransferase type Thing100002452.
- Chloramphenicol_acetyltransferase type Unit109465459.
- Chloramphenicol_acetyltransferase type Biomolecule.
- Chloramphenicol_acetyltransferase type Protein.
- Chloramphenicol_acetyltransferase type ProteinMolecule.
- Chloramphenicol_acetyltransferase type BiologicalObject.
- Chloramphenicol_acetyltransferase comment "Chloramphenicol acetyltransferase (or CAT) is a bacterial enzyme (EC 2.3.1.28) that detoxifies the antibiotic chloramphenicol and is responsible for chloramphenicol resistance in bacteria. This enzyme covalently attaches an acetyl group from acetyl-CoA to chloramphenicol, which prevents chloramphenicol from binding to ribosomes.".
- Chloramphenicol_acetyltransferase label "Chloramphenicol acetyltransferase".
- Chloramphenicol_acetyltransferase label "Chloramphenicol acétyltransférase".
- Chloramphenicol_acetyltransferase label "Cloramfenicolo O-acetiltransferasi".
- Chloramphenicol_acetyltransferase sameAs Chloramphenicol_acétyltransférase.
- Chloramphenicol_acetyltransferase sameAs Cloramfenicolo_O-acetiltransferasi.
- Chloramphenicol_acetyltransferase sameAs m.07d6hk.
- Chloramphenicol_acetyltransferase sameAs Q2964079.
- Chloramphenicol_acetyltransferase sameAs Q2964079.
- Chloramphenicol_acetyltransferase sameAs Chloramphenicol_acetyltransferase.
- Chloramphenicol_acetyltransferase wasDerivedFrom Chloramphenicol_acetyltransferase?oldid=584887974.
- Chloramphenicol_acetyltransferase depiction Chloramphenicol_acetyltransferase_3CLA_transparent.png.
- Chloramphenicol_acetyltransferase isPrimaryTopicOf Chloramphenicol_acetyltransferase.
