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- Cholangiocyte abstract "Cholangiocytes are the epithelial cells of the bile duct. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.In the healthy liver, cholangiocytes contribute to bile secretion via net release of bicarbonate and water. Several hormones and locally acting mediators are known to contribute to cholangiocyte fluid/electrolyte secretion. These include secretin, acetylcholine, ATP, and bombesin.Cholangiocytes act through bile-acid independent bile flow, which is driven by the active transport of electrolytes. In contrast, hepatocytes secrete bile through bile-acid dependent bile flow, which is coupled to canalicular secretion of bile acids via ATP-driven transporters. This results in passive transcellular and paracellular secretion of fluid and electrolytes through an osmotic effect.Importantly, cholangiocytes are the target of disease in a variety of conditions often known as "cholangiopathies". These diseases include primary biliary cirrhosis, primary sclerosing cholangitis, AIDS cholangiopathy, disappearing bile duct syndromes, Alagille's syndrome, cystic fibrosis, and biliary atresia. As a group, cholangiopathies account for approximately 18% of adult liver transplantations and the majority of pediatric liver transplantations.Active scientific investigation of cholangiocytes focuses on such diverse processes as mechanisms of fluid/electrolyte secretion, regulation of cholangiocyte proliferation, roles of cholangiocytes in the pathogenesis of liver fibrosis and cirrhosis, and cholangiocyte apoptosis. Specific investigation of individual cholangiopathies is also pursued actively.".
- Cholangiocyte wikiPageID "2730519".
- Cholangiocyte wikiPageRevisionID "593737674".
- Cholangiocyte code "TH H3.04.05.0.00011".
- Cholangiocyte hasPhotoCollection Cholangiocyte.
- Cholangiocyte latin "cholangiocytus".
- Cholangiocyte subject Category:Digestive_system.
- Cholangiocyte subject Category:Epithelial_cells.
- Cholangiocyte subject Category:Human_cells.
- Cholangiocyte type Abstraction100002137.
- Cholangiocyte type Anatomy106057539.
- Cholangiocyte type Biology106037666.
- Cholangiocyte type Cognition100023271.
- Cholangiocyte type Content105809192.
- Cholangiocyte type Discipline105996646.
- Cholangiocyte type KnowledgeDomain105999266.
- Cholangiocyte type LifeScience106037298.
- Cholangiocyte type Morphology106078327.
- Cholangiocyte type NaturalScience106000400.
- Cholangiocyte type PsychologicalFeature100023100.
- Cholangiocyte type Science105999797.
- Cholangiocyte type AnatomicalStructure.
- Cholangiocyte type BiologicalObject.
- Cholangiocyte comment "Cholangiocytes are the epithelial cells of the bile duct. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.In the healthy liver, cholangiocytes contribute to bile secretion via net release of bicarbonate and water. Several hormones and locally acting mediators are known to contribute to cholangiocyte fluid/electrolyte secretion.".
- Cholangiocyte label "Cholangiocyte".
- Cholangiocyte sameAs m.07_jsr.
- Cholangiocyte sameAs Q5104283.
- Cholangiocyte sameAs Q5104283.
- Cholangiocyte sameAs Cholangiocyte.
- Cholangiocyte wasDerivedFrom Cholangiocyte?oldid=593737674.
- Cholangiocyte isPrimaryTopicOf Cholangiocyte.