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- Chromothripsis abstract "Chromothripsis is the phenomenon by which up to thousands of clustered chromosomal rearrangements occur in a single event in localised and confined genomic regions in one or a few chromosomes, and is known to be involved in both cancer and congenital diseases. It occurs through one massive genomic rearrangement during a single catastrophic event in the cell's history. It is believed that for the cell to be able to withstand such a destructive event, the occurrence of such an event must be the upper limit of what a cell can tolerate and survive. The chromothripsis phenomenon opposes the conventional theory that cancer is the gradual acquisition of genomic rearrangements and somatic mutations over time.The simplest model as to how these rearrangements occur is through the simultaneous fragmentation of distinct chromosomal regions (breakpoints show a non-random distribution) and then subsequent imperfect reassembly by DNA repair pathways or aberrant DNA replication mechanisms. Chromothripsis occurs early in tumour development and leads to cellular transformation by loss of tumour suppressors and oncogene amplifications.Chromothripsis is a neologism that comes from the Greek words chromo which means color (and represents chromosomes because they are strongly stained by particular dyes) and thripsis which means 'shattering into pieces'.".
- Chromothripsis thumbnail Chromothripsis_the_result_of_a_single_catastrophic_event_in_a_cells_history.png?width=300.
- Chromothripsis wikiPageID "30517442".
- Chromothripsis wikiPageRevisionID "601325935".
- Chromothripsis hasPhotoCollection Chromothripsis.
- Chromothripsis subject Category:Chromosomes.
- Chromothripsis type Carcinogen114793812.
- Chromothripsis type Carcinogens.
- Chromothripsis type Consequence111410625.
- Chromothripsis type Matter100020827.
- Chromothripsis type Phenomenon100034213.
- Chromothripsis type PhysicalEntity100001930.
- Chromothripsis type Process100029677.
- Chromothripsis type RadiationHealthEffects.
- Chromothripsis type Substance100020090.
- Chromothripsis comment "Chromothripsis is the phenomenon by which up to thousands of clustered chromosomal rearrangements occur in a single event in localised and confined genomic regions in one or a few chromosomes, and is known to be involved in both cancer and congenital diseases. It occurs through one massive genomic rearrangement during a single catastrophic event in the cell's history.".
- Chromothripsis label "Chromothripsis".
- Chromothripsis label "Chromothripsis".
- Chromothripsis label "Cromotripsis".
- Chromothripsis label "Хромотрипсис".
- Chromothripsis label "クロモスリプシス".
- Chromothripsis sameAs Chromothripsis.
- Chromothripsis sameAs Cromotripsis.
- Chromothripsis sameAs クロモスリプシス.
- Chromothripsis sameAs m.0j66mmx.
- Chromothripsis sameAs Q1087765.
- Chromothripsis sameAs Q1087765.
- Chromothripsis sameAs Chromothripsis.
- Chromothripsis wasDerivedFrom Chromothripsis?oldid=601325935.
- Chromothripsis depiction Chromothripsis_the_result_of_a_single_catastrophic_event_in_a_cells_history.png.
- Chromothripsis isPrimaryTopicOf Chromothripsis.
