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• Cilnidipine abstract "Cilnidipine (INN) is a calcium channel blocker. It is sold as Atelec in Japan, & as CILACAR 5/10/20mg'in India. Effects of Cilnidipine compels to rethink on hypertension management.Clinidipine is the novel calcium antagonist accompanied with L-type and N-type calcium channel blocking function. It was jointly developed by Fuji Viscera Pharmaceutical Company, Japan and Ajinomoto, Japan and approved to come into market for the first time and used for high blood pressure treatment in 1995. Compared with other calcium antagonists, clinidipine can act on the N-type calcium-channel that existing sympathetic nerve end besides acting on L-type calcium-channel that similar to most of the calcium antagonists. Due to its N-type calcium-channel blocking properties, it has more advantages compared to conventional calcium-channel blockers. It has lower incidence of Pedal edema, one of the major adverse effects of other calcium channel blockers. Cilnidipine has similar blood pressure lowering efficacy as compared to amlodipine. One of the distinct property of cilnidipine from amlodipine is that it does not cause reflex tachycardia. Cilnidipine Advantages over AmlodipineOne of the main advantage of Cilnidipine is it REDUCES THE INCIDENCE OF PEDAL EDEMA UNLIKE AMLODIPINEL-type calcium channel blocker (Amlodipine) dilates the only arterioles & not the venules, hence blood pressure increases in the capillary bed and are thought to cause leg edema. Cilnidipine due to its blocking action at N-type calcium channel dilates both arteriole & venules as a result the pressure in the capillary bed is reduces. The accumulated fluid in the tissues flows back to veins & thus Cilnidipine minimizes the incidence of pedal edema.Superior Clinical benefits of Cilnidipine over AmlodipineCilnidipine controls hypertension for 24 hours with once daily dose. Cilnidipine has enhanced lipophilicity leading to prolonged antihypertensive effect correlated with occupancy of the binding site. In 24 hour clinical assessment, once-daily administration of cilnidipine (5–20 mg) produced BP reduction for 24 hour period. This indicates that once-daily cilnidipine exerts a sufficient and prolonged reduction of BP.2 Cilnidipine has 50 times higher selectivity for N-type of calcium channels than amlodipine. The inhibitory effect on the N-type Ca2+channel may bestow an additional clinical advantage for the treatment of hypertension, such as suppression of reflex tachycardia.3As catecholamines induce platelet activation via alpha 2-receptors on platelet membrane, decrease in norepinephrine level by cilnidipine (absent in amlodipine) causes attenuation of platelet activation. Cilnidipine significantly decreased urinary albumin excretion without affecting serum creatinine concentration in hypertensive patients.11 Cilnidipine is superior to amlodipine in preventing the progression of proteinuria in patients with hypertension and chronic renal disease.1 Cilnidipine suppresses the development of proteinuria greater than amlodipine through inhibiting N-type calcium channel-dependent podocyte injury.12 Cilnidipine leads to less activation of the RAAS compared with amlodipine and therefore cilnidipine might be expected to be superior in organ protection in addition to the anti-albuminuric effect.13 Cilnidipine inhibits proliferation of vascular smooth muscle cells through inhibition of DNA/ RNA synthesis induced by growth-promoting factors released during atherosclerosis."PLEIOTROPIC EFFECTS CILNIDIPINE COMPELS TO RETHINK ON HYPERTENSION MANAGEMENT Cilnidipine Improves baroreflex sensitivity, Improves NO availability, Ensures Antiproliferative effect, Inhibition of platelet activity, Exerts Antiarrhythmic effect, Reduction in Serum uric acid".
• Cilnidipine atcPrefix "C08".
• Cilnidipine atcSuffix "CA14".
• Cilnidipine casNumber "132203-70-4".
• Cilnidipine fdaUniiCode "97T5AZ1JIP".
• Cilnidipine iupacName "O3-(2-methoxyethyl) O5-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine- 3,5-dicarboxylate".
• Cilnidipine pubchem "5282138".
• Cilnidipine thumbnail Cilnidipine.svg?width=300.
• Cilnidipine wikiPageExternalLink e-product2.asp.
• Cilnidipine wikiPageID "17909920".
• Cilnidipine wikiPageRevisionID "606806818".
• Cilnidipine atcPrefix "8.0".
• Cilnidipine atcSuffix "CA14".
• Cilnidipine c "27".
• Cilnidipine casNumber "132203".
• Cilnidipine chemspiderid "4445338".
• Cilnidipine h "28".
• Cilnidipine hasPhotoCollection Cilnidipine.
• Cilnidipine iupacName "O3- O5-[-3-phenylprop-2-enyl] 2,6-dimethyl-4--1,4-dihydropyridine- 3,5-dicarboxylate".
• Cilnidipine kegg "D01173".
• Cilnidipine molecularWeight "492.52".
• Cilnidipine n "2".
• Cilnidipine o "7".
• Cilnidipine pubchem "5282138".
• Cilnidipine smiles "O=C\C2=CC".
• Cilnidipine unii "97".
• Cilnidipine subject Category:Calcium_channel_blockers.
• Cilnidipine subject Category:Carboxylate_esters.
• Cilnidipine subject Category:Dihydropyridines.
• Cilnidipine subject Category:Ethers.
• Cilnidipine subject Category:Nitro_compounds.
• Cilnidipine type Abstraction100002137.
• Cilnidipine type CarboxylateEsters.
• Cilnidipine type Chemical114806838.
• Cilnidipine type Cognition100023271.
• Cilnidipine type Compound105870180.
• Cilnidipine type Compound114818238.
• Cilnidipine type Concept105835747.
• Cilnidipine type Content105809192.
• Cilnidipine type Element114840755.
• Cilnidipine type Ester114850483.
• Cilnidipine type Ethers.
• Cilnidipine type Idea105833840.
• Cilnidipine type Material114580897.
• Cilnidipine type Matter100020827.
• Cilnidipine type NitroCompounds.
• Cilnidipine type OrganicCompound114727670.
• Cilnidipine type Part113809207.
• Cilnidipine type PhysicalEntity100001930.
• Cilnidipine type PsychologicalFeature100023100.
• Cilnidipine type Quintessence114847103.
• Cilnidipine type Relation100031921.
• Cilnidipine type Substance100019613.
• Cilnidipine type Whole105869584.
• Cilnidipine type Drug.
• Cilnidipine type DrugProduct.
• Cilnidipine type FunctionalSubstance.
• Cilnidipine comment "Cilnidipine (INN) is a calcium channel blocker. It is sold as Atelec in Japan, & as CILACAR 5/10/20mg'in India. Effects of Cilnidipine compels to rethink on hypertension management.Clinidipine is the novel calcium antagonist accompanied with L-type and N-type calcium channel blocking function. It was jointly developed by Fuji Viscera Pharmaceutical Company, Japan and Ajinomoto, Japan and approved to come into market for the first time and used for high blood pressure treatment in 1995.".
• Cilnidipine label "Cilnidipine".
• Cilnidipine label "シルニジピン".
• Cilnidipine sameAs シルニジピン.
• Cilnidipine sameAs m.047m0gv.
• Cilnidipine sameAs Q731525.
• Cilnidipine sameAs Q731525.
• Cilnidipine sameAs Cilnidipine.
• Cilnidipine wasDerivedFrom Cilnidipine?oldid=606806818.
• Cilnidipine depiction Cilnidipine.svg.
• Cilnidipine isPrimaryTopicOf Cilnidipine.