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- Cingulin-like_1 abstract "Cingulin-like 1 also known as paracingulin or junction-associated-coiled-coil protein (JACOP) is a protein which is encoded by the CGNL1 gene.The paracingulin polypeptide comprises a globular N-terminal "head" domain and an α-helical C-terminal domain which is presumed to form a coiled-coil dimer. Paracingulin is a paralog of cingulin that arose probably from gene duplication. The CGNL1 gene is conserved among different vertebrate species and has not been so far identified in invertebrates. The homology search highlights that paracingulin and cingulin have 39% identity in the rod tail sequences. They possess also two highly homologous regions in their N-terminus “head” domain including the ZIM region (ZO-1 interaction motif).The etymology of the name cingulin comes from the Latin "cingere" which means « to form a belt around ». Both, cingulin and paracingulin are localized in the cytoplasmic face of tight junctions (TJ). The prefix « para » refers to “paralog”. However, immunoelectron microscopy indicates that paracingulin is not only localized in the TJ but also in the adherens junctions (AJ) depending on tissue type. TJ and AJ together form the apical junctional complex (AJC) of vertebrate epithelial cells. The proteins present in this complex play a role in many cellular processes i.e., in the adhesion and barrier function of epithelia, the organization and dynamics of the cytoskeleton, as well as the regulation of Rho-GTPase family.Paracingulin interacts with cingulin and PLEKHA7 (as revealed by a yeast two-hybrid screen) as well as ZO-1, this latter through the ZIM region. JACOP is recruited to the TJ through interaction with ZO-1 (TJ-associated plaque protein, belonging to the membrane-associated guanylate kinase family) but is recruited to the AJ via interaction of it N-terminus head with PLEKHA7.Unlike cingulin, paracingulin associates with actin filaments in different types of culture cells and its localization at the apical junctional complex is perturbed by treatment with the microtubule drug nocodazole. Paracingulin regulates the activity of Rho family GTPases like RhoA, Rac1 and Cdc42 by interacting with their respective GEFs (guanine nucleotide exchange factor), GEF-H1, Tiam1 and GAPs to the epithelial junction during the formation of cell-cell junction. The regulation of these GTPases is crucial for cell growth, activation of kinases and cytoskeletal organization.".
- Cingulin-like_1 entrezgene "84952".
- Cingulin-like_1 wikiPageExternalLink MB_cgi?mode=&index=202864&field=all&HM=&II=&PA=&form=&input=.
- Cingulin-like_1 wikiPageID "19818063".
- Cingulin-like_1 wikiPageRevisionID "604100685".
- Cingulin-like_1 hasPhotoCollection Cingulin-like_1.
- Cingulin-like_1 type Biomolecule.
- Cingulin-like_1 type Protein.
- Cingulin-like_1 type ProteinMolecule.
- Cingulin-like_1 type BiologicalObject.
- Cingulin-like_1 comment "Cingulin-like 1 also known as paracingulin or junction-associated-coiled-coil protein (JACOP) is a protein which is encoded by the CGNL1 gene.The paracingulin polypeptide comprises a globular N-terminal "head" domain and an α-helical C-terminal domain which is presumed to form a coiled-coil dimer. Paracingulin is a paralog of cingulin that arose probably from gene duplication. The CGNL1 gene is conserved among different vertebrate species and has not been so far identified in invertebrates.".
- Cingulin-like_1 label "Cingulin-like 1".
- Cingulin-like_1 sameAs m.04q9gbg.
- Cingulin-like_1 sameAs Q5120919.
- Cingulin-like_1 sameAs Q5120919.
- Cingulin-like_1 wasDerivedFrom Cingulin-like_1?oldid=604100685.
- Cingulin-like_1 isPrimaryTopicOf Cingulin-like_1.