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- Clathrin_adaptor_proteins abstract "Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. These vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction of transport. Clathrin coats contain both clathrin (acts as a scaffold) and adaptor complexes that link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The two major types of clathrin adaptor complexes are the heterotetrameric adaptor protein (AP) complexes, and the monomeric GGA (Golgi-localising, Gamma-adaptin ear domain homology, ARF-binding proteins) adaptors.AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and lipids to clathrin at vesicle budding sites, as well as binding accessory proteins that regulate coat assembly and disassembly (such as AP180, epsins and auxilin). There are different AP complexes in mammals. AP1 is responsible for the transport of lysosomal hydrolases between the TGN and endosomes. AP2 adaptor complex associates with the plasma membrane and is responsible for endocytosis. AP3 is responsible for protein trafficking to lysosomes and other related organelles. AP4 is less well characterised. AP complexes are heterotetramers composed of two large subunits (adaptins), a medium subunit (mu) and a small subunit (sigma). For example, in AP1 these subunits are gamma-1-adaptin, beta-1-adaptin, mu-1 and sigma-1, while in AP2 they are alpha-adaptin, beta-2-adaptin, mu-2 and sigma-2. Each subunit has a specific function. Adaptins recognise and bind to clathrin through their hinge region (clathrin box), and recruit accessory proteins that modulate AP function through their C-terminal ear (appendage) domains. Mu recognises tyrosine-based sorting signals within the cytoplasmic domains of transmembrane cargo proteins. One function of clathrin and AP2 complex-mediated endocytosis is to regulate the number of GABA(A) receptors available at the cell surface .".
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- Clathrin_adaptor_proteins wikiPageRevisionID "593783948".
- Clathrin_adaptor_proteins hasPhotoCollection Clathrin_adaptor_proteins.
- Clathrin_adaptor_proteins subject Category:Peripheral_membrane_proteins.
- Clathrin_adaptor_proteins subject Category:Protein_families.
- Clathrin_adaptor_proteins type Abstraction100002137.
- Clathrin_adaptor_proteins type Family108078020.
- Clathrin_adaptor_proteins type Group100031264.
- Clathrin_adaptor_proteins type Organization108008335.
- Clathrin_adaptor_proteins type ProteinFamilies.
- Clathrin_adaptor_proteins type SocialGroup107950920.
- Clathrin_adaptor_proteins type Unit108189659.
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- Clathrin_adaptor_proteins comment "Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. These vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction of transport.".
- Clathrin_adaptor_proteins label "Clathrin adaptor proteins".
- Clathrin_adaptor_proteins sameAs m.0jl1fb5.
- Clathrin_adaptor_proteins sameAs Q5128484.
- Clathrin_adaptor_proteins sameAs Q5128484.
- Clathrin_adaptor_proteins sameAs Clathrin_adaptor_proteins.
- Clathrin_adaptor_proteins wasDerivedFrom Clathrin_adaptor_proteins?oldid=593783948.
- Clathrin_adaptor_proteins isPrimaryTopicOf Clathrin_adaptor_proteins.