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- Coagulation_factor_XIII,_A1_polypeptide abstract "Coagulation factor XIII A chain is a protein that in humans is encoded by the F13A1 gene.This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.".
- Coagulation_factor_XIII,_A1_polypeptide entrezgene "2162".
- Coagulation_factor_XIII,_A1_polypeptide wikiPageID "14116942".
- Coagulation_factor_XIII,_A1_polypeptide wikiPageRevisionID "593804656".
- Coagulation_factor_XIII,_A1_polypeptide hasPhotoCollection Coagulation_factor_XIII,_A1_polypeptide.
- Coagulation_factor_XIII,_A1_polypeptide requireManualInspection "no".
- Coagulation_factor_XIII,_A1_polypeptide summaryText "This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.".
- Coagulation_factor_XIII,_A1_polypeptide updateCitations "yes".
- Coagulation_factor_XIII,_A1_polypeptide updatePage "yes".
- Coagulation_factor_XIII,_A1_polypeptide updateProteinBox "yes".
- Coagulation_factor_XIII,_A1_polypeptide updateSummary "yes".
- Coagulation_factor_XIII,_A1_polypeptide type Biomolecule.
- Coagulation_factor_XIII,_A1_polypeptide type Protein.
- Coagulation_factor_XIII,_A1_polypeptide type BiologicalObject.
- Coagulation_factor_XIII,_A1_polypeptide comment "Coagulation factor XIII A chain is a protein that in humans is encoded by the F13A1 gene.This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules.".
- Coagulation_factor_XIII,_A1_polypeptide label "Coagulation factor XIII, A1 polypeptide".
- Coagulation_factor_XIII,_A1_polypeptide sameAs m.03cv41_.
- Coagulation_factor_XIII,_A1_polypeptide sameAs Q5137664.
- Coagulation_factor_XIII,_A1_polypeptide sameAs Q5137664.
- Coagulation_factor_XIII,_A1_polypeptide sameAs F13A1.
- Coagulation_factor_XIII,_A1_polypeptide sameAs 6.
- Coagulation_factor_XIII,_A1_polypeptide wasDerivedFrom Coagulation_factor_XIII,_A1_polypeptide?oldid=593804656.
- Coagulation_factor_XIII,_A1_polypeptide isPrimaryTopicOf Coagulation_factor_XIII,_A1_polypeptide.