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- Complement_receptor_1 abstract "Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1 gene.This gene is a member of the regulators of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, hyalocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.In primates, CR1 serves as the main system for processing and clearance of complement opsonized immune complexes. It has been shown that CR1 can act as a negative regulator of the complement cascade, mediate immune adherence and phagocytosis and inhibit both the classic and alternative pathways. The number of CR1 molecules decreases with aging of erythrocytes in normal individuals and is also decreased in pathological conditions such as systemic lupus erythematosus (SLE), HIV infection, some haemolytic anaemia s and other conditions featuring immune complexes. In mice, CR1 is an alternatively spliced variant of the complement receptor 2 (CR2) gene.Certain alleles of this gene have been statistically associated with an increased risk of developing late-onset Alzheimer's Disease.".
- Complement_receptor_1 entrezgene "1378".
- Complement_receptor_1 wikiPageExternalLink systems_info&system=knops.
- Complement_receptor_1 wikiPageID "1149539".
- Complement_receptor_1 wikiPageRevisionID "602994124".
- Complement_receptor_1 hasPhotoCollection Complement_receptor_1.
- Complement_receptor_1 requireManualInspection "no".
- Complement_receptor_1 target "haemolytic anaemia".
- Complement_receptor_1 type "decrease_associated_with_disease".
- Complement_receptor_1 updateCitations "yes".
- Complement_receptor_1 updatePage "yes".
- Complement_receptor_1 updateProteinBox "yes".
- Complement_receptor_1 updateSummary "no".
- Complement_receptor_1 subject Category:Blood_antigen_systems.
- Complement_receptor_1 subject Category:Clusters_of_differentiation.
- Complement_receptor_1 subject Category:Complement_system.
- Complement_receptor_1 subject Category:Transfusion_medicine.
- Complement_receptor_1 type Biomolecule.
- Complement_receptor_1 type Protein.
- Complement_receptor_1 type BiologicalObject.
- Complement_receptor_1 comment "Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1 gene.This gene is a member of the regulators of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, hyalocytes, and splenic follicular dendritic cells.".
- Complement_receptor_1 label "Complement receptor 1".
- Complement_receptor_1 sameAs CR1.
- Complement_receptor_1 sameAs m.04bk12.
- Complement_receptor_1 sameAs Q5156411.
- Complement_receptor_1 sameAs Q5156411.
- Complement_receptor_1 sameAs C3BR.
- Complement_receptor_1 sameAs CR1.
- Complement_receptor_1 wasDerivedFrom Complement_receptor_1?oldid=602994124.
- Complement_receptor_1 isPrimaryTopicOf Complement_receptor_1.