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• Copper_deficiency abstract "Copper deficiency is a very rare hematological and neurological disorder. The neurodegenerative syndrome of copper deficiency has been recognized for some time in ruminant animals, in which it is commonly known as "swayback" The disease involves a nutritional deficiency in the trace element copper. Copper is ubiquitous and daily requirement is low making acquired copper deficiency very rare. Copper deficiency can manifest in parallel with vitamin B12 and other nutritional deficiencies . The most common cause of copper deficiency is a remote gastrointestinal surgery, such as gastric bypass surgery, due to malabsorption of copper, or zinc toxicity. On the other hand, Menkes disease is a genetic disorder of copper deficiency involving a wide variety of symptoms that is often fatal.Copper is involved in normalized function of many enzymes, such as cytochrome c oxidase, which is complex IV in mitochondrial electron transport chain, ceruloplasmin, Cu/Zn superoxide dismutase, and in amine oxidases. These enzyme catalyze reactions for oxidative phosphorylation, iron transportation, antioxidant and free radical scavenging and neutralization, and neurotransmitter synthesis, respectively. A regular diet contains a variable amount of copper, but may provide 5 mg/day, of which only 20-50% is absorbed. The diet of the elderly may contain a lower copper content than the recommended daily intake. Dietary copper can be found in whole grain cereals, legumes, oysters, organ meats (particularly liver), cherries, dark chocolate, fruits, leafy green vegetables, nuts, poultry, prunes, and soybeans products like tofu. The deficiency in copper can cause many hematological manifestations, such as myelodysplasia, anemia, leukopenia (low white blood cell count) and neutropenia (low count of neutrophils, a type of white blood cell that is often called "the first line of defense" for the immune system). Copper deficiency has long been known for as a cause of myelodysplasia (when a blood profile has indicators of possible future leukemia development), but it was not until recently in 2001 that copper deficiency was associated with neurological manifestations. Some neurological manifestations can be sensory ataxia (irregular coordination due to proprioceptive loss), spasticity, muscle weakness, and more rarely visual loss due to peripheral neuropathy (damage in the peripheral nerves), myelopathy (disease of the spinal cord), and rarely optic neuropathy.".
• Copper_deficiency diseasesdb "3094".
• Copper_deficiency icd10 "E61.0".
• Copper_deficiency icd9 "275.1".
• Copper_deficiency omim "121270".
• Copper_deficiency thumbnail Ring_Sideroblast_smear_2010-01-13.JPG?width=300.
• Copper_deficiency wikiPageID "12542761".
• Copper_deficiency wikiPageRevisionID "601260333".
• Copper_deficiency diseasesdb "3094".
• Copper_deficiency hasPhotoCollection Copper_deficiency.
• Copper_deficiency icd "275.1".
• Copper_deficiency icd "E61.0".
• Copper_deficiency name "Copper deficiency".
• Copper_deficiency omim "121270".
• Copper_deficiency wordnet_type synset-disease-noun-1.
• Copper_deficiency subject Category:Animal_diseases.
• Copper_deficiency subject Category:Copper.
• Copper_deficiency subject Category:Mineral_deficiencies.
• Copper_deficiency type Abstraction100002137.
• Copper_deficiency type Attribute100024264.
• Copper_deficiency type Condition113920835.
• Copper_deficiency type Disease114070360.
• Copper_deficiency type IllHealth114052046.
• Copper_deficiency type Illness114061805.
• Copper_deficiency type Lack114449405.
• Copper_deficiency type MineralDeficiencies.
• Copper_deficiency type MineralDeficiency114450172.
• Copper_deficiency type Need114449126.
• Copper_deficiency type PathologicalState114051917.
• Copper_deficiency type PhysicalCondition114034177.
• Copper_deficiency type State100024720.
• Copper_deficiency type Disease.
• Copper_deficiency type AilmentCondition.
• Copper_deficiency type Situation.
• Copper_deficiency comment "Copper deficiency is a very rare hematological and neurological disorder. The neurodegenerative syndrome of copper deficiency has been recognized for some time in ruminant animals, in which it is commonly known as "swayback" The disease involves a nutritional deficiency in the trace element copper. Copper is ubiquitous and daily requirement is low making acquired copper deficiency very rare. Copper deficiency can manifest in parallel with vitamin B12 and other nutritional deficiencies .".
• Copper_deficiency label "Copper deficiency".
• Copper_deficiency label "Deficiencia de cobre".
• Copper_deficiency label "Kupfermangel".
• Copper_deficiency label "銅欠乏症".
• Copper_deficiency sameAs Kupfermangel.
• Copper_deficiency sameAs Χαλκοπενία.
• Copper_deficiency sameAs Deficiencia_de_cobre.
• Copper_deficiency sameAs 銅欠乏症.
• Copper_deficiency sameAs m.02wcf7n.
• Copper_deficiency sameAs Q1495005.
• Copper_deficiency sameAs Q1495005.
• Copper_deficiency sameAs Copper_deficiency.
• Copper_deficiency wasDerivedFrom Copper_deficiency?oldid=601260333.
• Copper_deficiency depiction Ring_Sideroblast_smear_2010-01-13.JPG.
• Copper_deficiency isPrimaryTopicOf Copper_deficiency.
• Copper_deficiency name "Copper deficiency".