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- Cortodoxone abstract "Cortodoxone, also known as cortexolone or 11-deoxycortisol, is a steroid that can be oxygenated to cortisol (hydrocortisone). It was first synthesized by Tadeusz Reichstein.On April 5, 1952, biochemist Durey Peterson and microbiologist Herbert Murray at Upjohn published the first report of a breakthrough fermentation process for the microbial 11α-oxygenation of steroids (e.g. progesterone) in a single step by common molds of the order Mucorales.11α-oxygenation of cortodoxone produces 11α-hydrocortisone, which can be chemically oxidized to cortisone, or converted by further chemical steps to cortisol.Subsequent fermentation processes for the microbial 11β-oxygenation of steroids in a single step were developed that could convert cortodoxone directly to cortisol.Cortodoxone functions as a glucocorticoid, though is less potent than cortisol. It can be synthesized from 17-hydroxyprogesterone. In 11β-hydroxylase deficiency, cortodoxone levels increase dramatically, causing hypertension (as opposed to 21α-hydroxylase deficiency, in which patients have hypotension from a lack of mineralocorticoids).Cortodoxone can also be converted to androstenedione. This could explain, at least in part, the marked increase in androstenedione levels in 11β-hydroxylase deficiency.".
- Cortodoxone iupacName "(8R,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one".
- Cortodoxone thumbnail Cortodoxone.png?width=300.
- Cortodoxone wikiPageID "22312974".
- Cortodoxone wikiPageRevisionID "594339502".
- Cortodoxone hasPhotoCollection Cortodoxone.
- Cortodoxone imagealt "Cortodoxone molecule".
- Cortodoxone imagefile "Cortodoxone-3D-balls.png".
- Cortodoxone imagefile "Cortodoxone.png".
- Cortodoxone imagesize "220".
- Cortodoxone iupacname "-17".
- Cortodoxone iupacnameHidden "yes".
- Cortodoxone othernames "11".
- Cortodoxone verifiedfields "changed".
- Cortodoxone verifiedrevid "396318614".
- Cortodoxone watchedfields "changed".
- Cortodoxone subject Category:Steroids.
- Cortodoxone type Abstraction100002137.
- Cortodoxone type Chemical114806838.
- Cortodoxone type Compound114818238.
- Cortodoxone type Material114580897.
- Cortodoxone type Matter100020827.
- Cortodoxone type OrganicCompound114727670.
- Cortodoxone type Part113809207.
- Cortodoxone type PhysicalEntity100001930.
- Cortodoxone type Relation100031921.
- Cortodoxone type Steroid115057744.
- Cortodoxone type Steroids.
- Cortodoxone type Substance100019613.
- Cortodoxone type ChemicalCompound.
- Cortodoxone type ChemicalSubstance.
- Cortodoxone type ChemicalSubstanceType.
- Cortodoxone type ChemicalObject.
- Cortodoxone type Thing.
- Cortodoxone comment "Cortodoxone, also known as cortexolone or 11-deoxycortisol, is a steroid that can be oxygenated to cortisol (hydrocortisone). It was first synthesized by Tadeusz Reichstein.On April 5, 1952, biochemist Durey Peterson and microbiologist Herbert Murray at Upjohn published the first report of a breakthrough fermentation process for the microbial 11α-oxygenation of steroids (e.g.".
- Cortodoxone label "11-désoxycortisol".
- Cortodoxone label "11-деоксикортизол".
- Cortodoxone label "Cortodoxone".
- Cortodoxone sameAs 11-désoxycortisol.
- Cortodoxone sameAs m.05s_f3x.
- Cortodoxone sameAs Q2064915.
- Cortodoxone sameAs Q2064915.
- Cortodoxone sameAs Cortodoxone.
- Cortodoxone wasDerivedFrom Cortodoxone?oldid=594339502.
- Cortodoxone depiction Cortodoxone.png.
- Cortodoxone isPrimaryTopicOf Cortodoxone.
