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- Creb_binding_domain abstract "In molecular biology, the creb binding domain is a protein domain. It is the interlocking domain of the eukaryotic nuclear receptor coactivators CREBBP and P300. This interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target.Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes, including development, reproduction and homeostasis. Nuclear receptor coactivators act to modulate the function of nuclear receptors. Coactivators associate with promoters and enhancers primarily through protein-protein contacts to facilitate the interaction between DNA-bound transcription factors and the transcription machinery. Many of these coactivators are structurally related, including CBP (CREB-binding protein, CREBBP) and P300. CBP and P300 both have histone acetyltransferase activity. CBP/P300 proteins function synergistically to activate transcription, acting to remodel chromatin and to recruit RNA polymerase II and the basal transcription machinery. CBP is required for proper cell cycle control, differentiation and apoptosis. The interaction of CBP/P300 with transcription factors involves several small domains. The IBiD domain in the C-terminal of CBP is responsible for CBP interaction with IRF-3, as well as with the adenoviral oncoprotein E1A, TIF-2 coactivator, and the IRF homologue KSHV IRF-1.".
- Creb_binding_domain symbol "Creb_binding".
- Creb_binding_domain thumbnail PDB_1zoq_EBI.jpg?width=300.
- Creb_binding_domain wikiPageID "32345601".
- Creb_binding_domain wikiPageRevisionID "593871637".
- Creb_binding_domain caption "irf3-cbp complex".
- Creb_binding_domain hasPhotoCollection Creb_binding_domain.
- Creb_binding_domain interpro "IPR014744".
- Creb_binding_domain name "Creb binding".
- Creb_binding_domain pfam "PF09030".
- Creb_binding_domain symbol "Creb_binding".
- Creb_binding_domain subject Category:Protein_domains.
- Creb_binding_domain type Abstraction100002137.
- Creb_binding_domain type Attribute100024264.
- Creb_binding_domain type Environment113934596.
- Creb_binding_domain type ProteinDomains.
- Creb_binding_domain type Situation113927383.
- Creb_binding_domain type Sphere114514039.
- Creb_binding_domain type State100024720.
- Creb_binding_domain type Biomolecule.
- Creb_binding_domain type Protein.
- Creb_binding_domain type BiologicalObject.
- Creb_binding_domain comment "In molecular biology, the creb binding domain is a protein domain. It is the interlocking domain of the eukaryotic nuclear receptor coactivators CREBBP and P300. This interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target.Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes, including development, reproduction and homeostasis.".
- Creb_binding_domain label "Creb binding domain".
- Creb_binding_domain sameAs m.0gyrqbq.
- Creb_binding_domain sameAs Q5183674.
- Creb_binding_domain sameAs Q5183674.
- Creb_binding_domain sameAs Creb_binding_domain.
- Creb_binding_domain wasDerivedFrom Creb_binding_domain?oldid=593871637.
- Creb_binding_domain depiction PDB_1zoq_EBI.jpg.
- Creb_binding_domain isPrimaryTopicOf Creb_binding_domain.
