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- Crick,_Brenner_et_al._experiment abstract "The Crick, Brenner, Barnett, Watts-Tobin experiment of 1961 was a scientific experiment performed in 1961 by Francis Crick, Sydney Brenner, Leslie Barnett and R.J. Watts-Tobin. They demonstrated that three bases of DNA code for one amino acid in the genetic code. The experiment elucidated the nature of gene expression and frame-shift mutations. In the experiment, proflavin-induced mutations of the T4 bacteriophage gene, rIIB, were isolated. Proflavin causes mutations by inserting itself between DNA bases, typically resulting in insertion or deletion of a single base pair.The mutants produced by Crick and Brenner could not produce functional rIIB protein because the insertion or deletion of a single nucleotide caused a frameshift mutation. Mutants with two or four nucleotides inserted or deleted were also nonfunctional. However, the mutant strains could be made functional again by using proflavin to insert or delete a total of three nucleotides. This proved that the genetic code uses a codon of three DNA bases that corresponds to an amino acid.".
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- Crick,_Brenner_et_al._experiment subject Category:1961_in_science.
- Crick,_Brenner_et_al._experiment subject Category:Genetics_experiments.
- Crick,_Brenner_et_al._experiment type Abstraction100002137.
- Crick,_Brenner_et_al._experiment type Act100030358.
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- Crick,_Brenner_et_al._experiment type Event100029378.
- Crick,_Brenner_et_al._experiment type Experiment100639556.
- Crick,_Brenner_et_al._experiment type GeneticsExperiments.
- Crick,_Brenner_et_al._experiment type Investigation100633864.
- Crick,_Brenner_et_al._experiment type PsychologicalFeature100023100.
- Crick,_Brenner_et_al._experiment type Research100636921.
- Crick,_Brenner_et_al._experiment type ScientificResearch100641820.
- Crick,_Brenner_et_al._experiment type Work100575741.
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- Crick,_Brenner_et_al._experiment comment "The Crick, Brenner, Barnett, Watts-Tobin experiment of 1961 was a scientific experiment performed in 1961 by Francis Crick, Sydney Brenner, Leslie Barnett and R.J. Watts-Tobin. They demonstrated that three bases of DNA code for one amino acid in the genetic code. The experiment elucidated the nature of gene expression and frame-shift mutations. In the experiment, proflavin-induced mutations of the T4 bacteriophage gene, rIIB, were isolated.".
- Crick,_Brenner_et_al._experiment label "Crick, Brenner et al. experiment".
- Crick,_Brenner_et_al._experiment sameAs m.02wb76.
- Crick,_Brenner_et_al._experiment sameAs Q5184931.
- Crick,_Brenner_et_al._experiment sameAs Q5184931.
- Crick,_Brenner_et_al._experiment sameAs Crick,_Brenner_et_al._experiment.
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