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- CyaA abstract "Bifunctional hemolysin/adenylate cyclase is a protein that in B. pertussis (the bacteria that causes whooping cough) is encoded by the cyaA gene. This protein in turn is cleaved into a calmodulin-sensitive adenylate cyclase (cyaA–ACD) and hemolysin. Both are virulence factors facilitating respiratory tract colonization by B. pertussis. The cyaA–ACD binds to a M2 integrin cell surface receptor and inserts its N-terminal adenylyl cyclase domain into the cytosol. After binding to calmodulin, cyaA–ACD catalyzes the cyclization of AMP into cAMP. This catalysis raises the intracellular concentration of cAMP to toxic levels.".
- CyaA ecNumber "4.6.1.1".
- CyaA entrezgene "2661688".
- CyaA pdb "2COL".
- CyaA symbol "cyaA".
- CyaA thumbnail CyaA.png?width=300.
- CyaA uniprot "P15318".
- CyaA wikiPageID "29805629".
- CyaA wikiPageRevisionID "593923130".
- CyaA caption "Crystal structure of the N-terminal adenylyl cyclase domain of B. pertussis cyaA complexed with the C-terminal domain of Xenopus calmodulin.".
- CyaA ecnumber "4.6".
- CyaA entrezgene "2661688".
- CyaA hasPhotoCollection CyaA.
- CyaA name "Bifunctional hemolysin-adenylate cyclase precursor".
- CyaA pdb "2".
- CyaA symbol "cyaA".
- CyaA uniprot "P15318".
- CyaA subject Category:EC_4.6.1.
- CyaA subject Category:Pertussis.
- CyaA type Abstraction100002137.
- CyaA type Chemical114806838.
- CyaA type Compound114818238.
- CyaA type Macromolecule114944888.
- CyaA type Material114580897.
- CyaA type Matter100020827.
- CyaA type Molecule114682133.
- CyaA type OrganicCompound114727670.
- CyaA type Part113809207.
- CyaA type PhysicalEntity100001930.
- CyaA type Protein114728724.
- CyaA type Relation100031921.
- CyaA type Substance100019613.
- CyaA type Thing100002452.
- CyaA type Unit109465459.
- CyaA type Biomolecule.
- CyaA type Protein.
- CyaA type BiologicalObject.
- CyaA comment "Bifunctional hemolysin/adenylate cyclase is a protein that in B. pertussis (the bacteria that causes whooping cough) is encoded by the cyaA gene. This protein in turn is cleaved into a calmodulin-sensitive adenylate cyclase (cyaA–ACD) and hemolysin. Both are virulence factors facilitating respiratory tract colonization by B. pertussis. The cyaA–ACD binds to a M2 integrin cell surface receptor and inserts its N-terminal adenylyl cyclase domain into the cytosol.".
- CyaA label "CyaA".
- CyaA sameAs m.0fq256c.
- CyaA sameAs Q5197350.
- CyaA sameAs Q5197350.
- CyaA sameAs CyaA.
- CyaA wasDerivedFrom CyaA?oldid=593923130.
- CyaA depiction CyaA.png.
- CyaA isPrimaryTopicOf CyaA.
- CyaA name "Bifunctional hemolysin-adenylate cyclase precursor".
