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- Cyclin_A1 abstract "Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell division cycle. Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases (CDKs). Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of cell cycle events. Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of meiosis. This cyclin binds both Cdk1 and Cdk2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F1, and the Kip/Cip family of CDK-inhibitor proteins.".
- Cyclin_A1 entrezgene "8900".
- Cyclin_A1 wikiPageID "14156499".
- Cyclin_A1 wikiPageRevisionID "593927128".
- Cyclin_A1 hasPhotoCollection Cyclin_A1.
- Cyclin_A1 requireManualInspection "no".
- Cyclin_A1 summaryText "The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell division cycle. Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases (CDKs). Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of cell cycle events. Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of meiosis. This cyclin binds both Cdk1 and Cdk2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F1, and the Kip/Cip family of CDK-inhibitor proteins.".
- Cyclin_A1 updateCitations "yes".
- Cyclin_A1 updatePage "yes".
- Cyclin_A1 updateProteinBox "yes".
- Cyclin_A1 updateSummary "yes".
- Cyclin_A1 type Biomolecule.
- Cyclin_A1 type Protein.
- Cyclin_A1 type BiologicalObject.
- Cyclin_A1 comment "Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell division cycle. Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases (CDKs).".
- Cyclin_A1 label "Ciclina A1".
- Cyclin_A1 label "Cyclin A1".
- Cyclin_A1 label "周期蛋白A1".
- Cyclin_A1 sameAs Ciclina_A1.
- Cyclin_A1 sameAs m.03cw8wt.
- Cyclin_A1 sameAs Q5198262.
- Cyclin_A1 sameAs Q5198262.
- Cyclin_A1 wasDerivedFrom Cyclin_A1?oldid=593927128.
- Cyclin_A1 isPrimaryTopicOf Cyclin_A1.