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- Cystinyl_aminopeptidase abstract "Leucyl-cystinyl aminopeptidase also known as insulin regulated aminopeptidase (IRAP) is an enzyme that in humans is encoded by the LNPEP gene.This gene encodes a zinc-dependent aminopeptidase (metalloexopeptidase) that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.Mutations in this gene have been associated to psoriasis risk.(doi:10.1038/jid.2013.317)".
- Cystinyl_aminopeptidase entrezgene "4012".
- Cystinyl_aminopeptidase wikiPageExternalLink merops.cgi?id=M01.011.
- Cystinyl_aminopeptidase wikiPageID "6121088".
- Cystinyl_aminopeptidase wikiPageRevisionID "593934981".
- Cystinyl_aminopeptidase hasPhotoCollection Cystinyl_aminopeptidase.
- Cystinyl_aminopeptidase requireManualInspection "no".
- Cystinyl_aminopeptidase summaryText "This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.".
- Cystinyl_aminopeptidase updateCitations "yes".
- Cystinyl_aminopeptidase updatePage "yes".
- Cystinyl_aminopeptidase updateProteinBox "yes".
- Cystinyl_aminopeptidase updateSummary "no".
- Cystinyl_aminopeptidase type Biomolecule.
- Cystinyl_aminopeptidase type Protein.
- Cystinyl_aminopeptidase type BiologicalObject.
- Cystinyl_aminopeptidase comment "Leucyl-cystinyl aminopeptidase also known as insulin regulated aminopeptidase (IRAP) is an enzyme that in humans is encoded by the LNPEP gene.This gene encodes a zinc-dependent aminopeptidase (metalloexopeptidase) that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones.".
- Cystinyl_aminopeptidase label "Cystinyl aminopeptidase".
- Cystinyl_aminopeptidase label "Oksytocynaza".
- Cystinyl_aminopeptidase sameAs Oksytocynaza.
- Cystinyl_aminopeptidase sameAs m.0fr5p_.
- Cystinyl_aminopeptidase sameAs Q5201223.
- Cystinyl_aminopeptidase sameAs Q5201223.
- Cystinyl_aminopeptidase wasDerivedFrom Cystinyl_aminopeptidase?oldid=593934981.
- Cystinyl_aminopeptidase isPrimaryTopicOf Cystinyl_aminopeptidase.