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- DAB1 abstract "The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells. DAB1 functions downstream of Reln in a signaling pathwaythat controls cell positioning in the developing brain and during adult neurogenesis. It docks to the intracellular part of the Reelin very low density lipoprotein receptor (VLDLR) and apoE receptor type 2 (ApoER2) and becomes tyrosine-phosphorylated following binding of Reelin to cortical neurons. In mice, mutations of Dab1 and Reelin generate identical phenotypes. In humans, Reelin mutations are associated with brain malformations and mental retardation. In mice, Dab1 mutation results in the scrambler mouse phenotype.With a genomic length of 1.1 Mbp for a coding region of 5.5 kb, DAB1 provides a rare example of genomic complexity, which will impede the identification of human mutations.".
- DAB1 entrezgene "1600".
- DAB1 wikiPageExternalLink h_reelinPathway.asp.
- DAB1 wikiPageID "5139079".
- DAB1 wikiPageRevisionID "593939241".
- DAB1 hasPhotoCollection DAB1.
- DAB1 subject Category:Central_nervous_system.
- DAB1 subject Category:Human_genes.
- DAB1 subject Category:Molecular_neuroscience.
- DAB1 subject Category:Peripheral_membrane_proteins.
- DAB1 subject Category:Phosphoproteins.
- DAB1 type Biomolecule.
- DAB1 type Protein.
- DAB1 type BiologicalObject.
- DAB1 comment "The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells. DAB1 functions downstream of Reln in a signaling pathwaythat controls cell positioning in the developing brain and during adult neurogenesis.".
- DAB1 label "DAB1".
- DAB1 label "DAB1".
- DAB1 sameAs m.0d4k9k.
- DAB1 sameAs Q4036848.
- DAB1 sameAs Q4036848.
- DAB1 wasDerivedFrom DAB1?oldid=593939241.
- DAB1 isPrimaryTopicOf DAB1.