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- DASB abstract "DASB is a compound that binds to the serotonin transporter.Labeled with carbon-11 — a radioactive isotope — it has been used as a radioligand in neuroimaging with positron emission tomography (PET) since around year 2000.In this context it is regarded as one of the superior radioligands for PET study of the serotonin transporter in the brain,since it has high selectivity for the serotonin transporter.The DASB image from a human PET scan shows high binding in the midbrain, thalamus and striatum, moderate binding in the medial temporal lobe and anterior cingulate, and low binding in neocortex.The cerebellum is often regarded as a region with no specific serotonin transporter binding and the brain region is used as a reference in some studies.Since the serotonin transporter is the target of SSRIs used in the treatment of major depression it has been natural to examine DASB binding in depressed patients.Several such research studies have been performed.There are a number of alternative PET radioligands for imaging the serotonin transporter: [11C]ADAM, [11C]AFM, [11C]DAPA, [11C]McN5652, and [11C]-NS 4194.A related molecule to DASB, that can be labeled with fluorine-18, has also been suggested as a PET radioligand. With single-photon emission computed tomography (SPECT) using the radioisotope iodine-123 there are further radioligands available: [123I]ODAM, [123I]IDAM, [123I]ADAM, and [123I]β-CIT.A few studies have examined the difference in binding between the radioligands in nonhuman primates, as well as in pigs.Other compounds that can be labeled to work as PET radioligands for the study of the serotonin system are, e.g., altanserin and WAY-100635.".
- DASB iupacName "3-amino-4-[2-[(di(methyl)amino)methyl]phenyl]sulfanylbenzonitrile".
- DASB pubchem "10446567".
- DASB thumbnail DASB.png?width=300.
- DASB wikiPageID "15378722".
- DASB wikiPageRevisionID "606679619".
- DASB c "16".
- DASB chemspiderid "570800".
- DASB chemspiderid "8621986".
- DASB chemspiderid1Comment "11".
- DASB h "17".
- DASB hasPhotoCollection DASB.
- DASB image "DASB C-11.png".
- DASB imagename "DASB and [C-11]DASB".
- DASB inchi "1".
- DASB inchi1Comment "11".
- DASB inchikey "UVWLEPXXYOYDGR-BJUDXGSMEM".
- DASB inchikey "UVWLEPXXYOYDGR-UHFFFAOYAE".
- DASB inchikey1Comment "11".
- DASB iupacName "3".
- DASB molecularWeight "282.392014".
- DASB n "3".
- DASB pubchem "10446567".
- DASB pubchem "656408".
- DASB pubchem1Comment "11".
- DASB s "1".
- DASB smiles "CNCc1ccccc1Sc2cccC#N".
- DASB smiles "N#Cc2ccccN".
- DASB smiles1Comment "11".
- DASB stdinchi "1".
- DASB stdinchi1Comment "11".
- DASB stdinchikey "UVWLEPXXYOYDGR-BJUDXGSMSA-N".
- DASB stdinchikey "UVWLEPXXYOYDGR-UHFFFAOYSA-N".
- DASB stdinchikey1Comment "11".
- DASB verifiedfields "changed".
- DASB verifiedrevid "429877266".
- DASB watchedfields "changed".
- DASB subject Category:Nitriles.
- DASB subject Category:Thioethers.
- DASB subject Category:Treatment_of_bipolar_disorder.
- DASB type Artifact100021939.
- DASB type Container103094503.
- DASB type Conveyance103100490.
- DASB type Instrumentality103575240.
- DASB type MotorVehicle103791235.
- DASB type NeurotransmitterTransporters.
- DASB type Object100002684.
- DASB type PhysicalEntity100001930.
- DASB type Self-propelledVehicle104170037.
- DASB type Transporter104474035.
- DASB type Truck104490091.
- DASB type Vehicle104524313.
- DASB type WheeledVehicle104576211.
- DASB type Whole100003553.
- DASB type Drug.
- DASB type DrugProduct.
- DASB type FunctionalSubstance.
- DASB comment "DASB is a compound that binds to the serotonin transporter.Labeled with carbon-11 — a radioactive isotope — it has been used as a radioligand in neuroimaging with positron emission tomography (PET) since around year 2000.In this context it is regarded as one of the superior radioligands for PET study of the serotonin transporter in the brain,since it has high selectivity for the serotonin transporter.The DASB image from a human PET scan shows high binding in the midbrain, thalamus and striatum, moderate binding in the medial temporal lobe and anterior cingulate, and low binding in neocortex.The cerebellum is often regarded as a region with no specific serotonin transporter binding and the brain region is used as a reference in some studies.Since the serotonin transporter is the target of SSRIs used in the treatment of major depression it has been natural to examine DASB binding in depressed patients.Several such research studies have been performed.There are a number of alternative PET radioligands for imaging the serotonin transporter: [11C]ADAM, [11C]AFM, [11C]DAPA, [11C]McN5652, and [11C]-NS 4194.A related molecule to DASB, that can be labeled with fluorine-18, has also been suggested as a PET radioligand. ".
- DASB label "DASB".
- DASB sameAs m.03m6ltz.
- DASB sameAs Q5204319.
- DASB sameAs Q5204319.
- DASB sameAs DASB.
- DASB wasDerivedFrom DASB?oldid=606679619.
- DASB depiction DASB.png.
- DASB isPrimaryTopicOf DASB.
