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- DDR1 abstract "Discoidin domain receptor family, member 1, also known as DDR1 or CD167a (cluster of differentiation 167a), is a human gene.Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). A closely related family member is the DDR2 protein. In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.".
- DDR1 entrezgene "780".
- DDR1 wikiPageID "14754020".
- DDR1 wikiPageRevisionID "598367886".
- DDR1 hasPhotoCollection DDR1.
- DDR1 requireManualInspection "no".
- DDR1 summaryText "Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested . A closely related family member is the DDR2 protein. In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.".
- DDR1 updateCitations "yes".
- DDR1 updatePage "yes".
- DDR1 updateProteinBox "yes".
- DDR1 updateSummary "yes".
- DDR1 subject Category:Clusters_of_differentiation.
- DDR1 type Biomolecule.
- DDR1 type Protein.
- DDR1 type BiologicalObject.
- DDR1 comment "Discoidin domain receptor family, member 1, also known as DDR1 or CD167a (cluster of differentiation 167a), is a human gene.Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen.".
- DDR1 label "DDR1".
- DDR1 label "DDR1".
- DDR1 sameAs m.03gwq19.
- DDR1 sameAs Q4036864.
- DDR1 sameAs Q4036864.
- DDR1 sameAs 1950.
- DDR1 wasDerivedFrom DDR1?oldid=598367886.
- DDR1 isPrimaryTopicOf DDR1.