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- DEP_domain abstract "In molecular biology, the DEP domain (Dishevelled, Egl-10 and Pleckstrin domain) is a globular protein domain of about 80 amino acids that is found in over 50 proteins involved in G-protein signalling pathways. It was named after the three proteins it was initially found in:Dishevelled (Dsh and Dvl), which plays a key role in the transduction of the Wg/Wnt signal from the cell surface to the nucleus; it is a segment polarity protein required to establish coherent arrays of polarised cells and segments in embryos, and plays a role in wingless signalling.Egl-10, which regulates G-protein signalling in the central nervous system in RGS9.Pleckstrin, the major substrate of protein kinase C in platelets; Pleckstrin contains two PH domains flanking the DEP domain.Mammalian regulators of G-protein signalling also contain these domains, and regulate signal transduction by increasing the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form. It has been proposed that the DEP domain could play a selective role in targeting DEP domain-containing proteins to specific subcellular membranous sites, perhaps even to specific G protein-coupled signaling pathways. Nuclear magnetic resonance spectroscopy has revealed that the DEP domain comprises a three-helix bundle, a beta-hairpin 'arm' composed of two beta-strands and two short beta-strands in the C-terminal region.".
- DEP_domain symbol "DEP".
- DEP_domain thumbnail PDB_1fsh_EBI.jpg?width=300.
- DEP_domain wikiPageID "32601681".
- DEP_domain wikiPageRevisionID "590977778".
- DEP_domain caption "structural basis of the recognition of the dishevelled dep domain in the wnt signaling pathway".
- DEP_domain hasPhotoCollection DEP_domain.
- DEP_domain interpro "IPR000591".
- DEP_domain name "Domain found in Dishevelled, Egl-10, and Pleckstrin".
- DEP_domain pfam "PF00610".
- DEP_domain symbol "DEP".
- DEP_domain subject Category:Protein_domains.
- DEP_domain type Abstraction100002137.
- DEP_domain type Attribute100024264.
- DEP_domain type Environment113934596.
- DEP_domain type ProteinDomains.
- DEP_domain type Situation113927383.
- DEP_domain type Sphere114514039.
- DEP_domain type State100024720.
- DEP_domain type Biomolecule.
- DEP_domain type Protein.
- DEP_domain type BiologicalObject.
- DEP_domain comment "In molecular biology, the DEP domain (Dishevelled, Egl-10 and Pleckstrin domain) is a globular protein domain of about 80 amino acids that is found in over 50 proteins involved in G-protein signalling pathways.".
- DEP_domain label "DEP domain".
- DEP_domain sameAs m.0h1dgjk.
- DEP_domain sameAs Q5204853.
- DEP_domain sameAs Q5204853.
- DEP_domain sameAs DEP_domain.
- DEP_domain wasDerivedFrom DEP_domain?oldid=590977778.
- DEP_domain depiction PDB_1fsh_EBI.jpg.
- DEP_domain isPrimaryTopicOf DEP_domain.
