Matches in DBpedia 2014 for { <http://dbpedia.org/resource/DFFB> ?p ?o. }
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- DFFB abstract "DNA fragmentation factor subunit beta is a protein that in humans is encoded by the DFFB gene.Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.".
- DFFB entrezgene "1677".
- DFFB symbol "DFF40".
- DFFB thumbnail PDB_1v0d_EBI.jpg?width=300.
- DFFB wikiPageID "14755493".
- DFFB wikiPageRevisionID "601763936".
- DFFB caption "crystal structure of caspase-activated dnase".
- DFFB hasPhotoCollection DFFB.
- DFFB interpro "IPR015311".
- DFFB name "DNA fragmentation factor 40 kDa".
- DFFB pfam "PF09230".
- DFFB requireManualInspection "no".
- DFFB scop "0.0".
- DFFB summaryText "Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor is a heterodimeric protein of 40-kD and 45-kD subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.".
- DFFB symbol "DFF40".
- DFFB updateCitations "yes".
- DFFB updatePage "yes".
- DFFB updateProteinBox "yes".
- DFFB updateSummary "yes".
- DFFB type Biomolecule.
- DFFB type Protein.
- DFFB type BiologicalObject.
- DFFB comment "DNA fragmentation factor subunit beta is a protein that in humans is encoded by the DFFB gene.Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits.".
- DFFB label "DFFB".
- DFFB sameAs m.03gwt5q.
- DFFB sameAs Q5204912.
- DFFB sameAs Q5204912.
- DFFB wasDerivedFrom DFFB?oldid=601763936.
- DFFB depiction PDB_1v0d_EBI.jpg.
- DFFB isPrimaryTopicOf DFFB.
