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- DM_domain abstract "In molecular biology the DM domain is a protein domain first discovered in the doublesex proteins of Drosophila melanogaster and is also seen in proteins from Caenorhabditis elegans. In D. melanogaster the doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides. These proteins are believed to function as transcription factors on downstream sex-determination genes, especially on neuroblast differentiation and yolk protein genes transcription. The DM domain binds DNA as a dimer, allowing the recognition of pseudopalindromic sequences . The NMR analysis of the DSX DM domain revealed a novel zinc module containing 'intertwined' CCHC and HCCC zinc-binding sites. The recognition of the DNA requires the carboxy-terminal basic tail which contacts the minor groove of the target sequence.".
- DM_domain symbol "DM".
- DM_domain thumbnail PDB_1lpv_EBI.jpg?width=300.
- DM_domain wikiPageID "31890027".
- DM_domain wikiPageRevisionID "591035127".
- DM_domain caption "drosophila melanogaster doublesex , nmr, 18 structures".
- DM_domain hasPhotoCollection DM_domain.
- DM_domain interpro "IPR001275".
- DM_domain name "DM domain".
- DM_domain pfam "PF00751".
- DM_domain scop "1".
- DM_domain smart "SM00718".
- DM_domain symbol "DM".
- DM_domain subject Category:Protein_domains.
- DM_domain subject Category:Protein_families.
- DM_domain type Abstraction100002137.
- DM_domain type Family108078020.
- DM_domain type Group100031264.
- DM_domain type Organization108008335.
- DM_domain type ProteinFamilies.
- DM_domain type SocialGroup107950920.
- DM_domain type Unit108189659.
- DM_domain type YagoLegalActor.
- DM_domain type YagoLegalActorGeo.
- DM_domain type YagoPermanentlyLocatedEntity.
- DM_domain type Biomolecule.
- DM_domain type Protein.
- DM_domain type BiologicalObject.
- DM_domain comment "In molecular biology the DM domain is a protein domain first discovered in the doublesex proteins of Drosophila melanogaster and is also seen in proteins from Caenorhabditis elegans. In D. melanogaster the doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides.".
- DM_domain label "DM domain".
- DM_domain sameAs m.0gvsmk2.
- DM_domain sameAs Q5205666.
- DM_domain sameAs Q5205666.
- DM_domain sameAs DM_domain.
- DM_domain wasDerivedFrom DM_domain?oldid=591035127.
- DM_domain depiction PDB_1lpv_EBI.jpg.
- DM_domain isPrimaryTopicOf DM_domain.
