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- DNA_fragmentation abstract "DNA fragmentation is the separation or breaking of DNA strands into pieces. It can be intentional by laboratory personnel or the cells, or it can be spontaneous. Spontaneous or accidental DNA fragmentation is fragmentation that gradually accumulates in a cell. It can be measured by e.g. Comet assay. The degree of DNA fragmentation can predict outcomes for in vitro fertilization (IVF) and its expansion intracytoplasmic sperm injection (ICSI). The sperm chromatin dispersion test (SCD) and TUNEL assay are both effective in detecting sperm DNA damage. Using bright-field microscopy, the SCD test appears to be more sensitive than the TUNEL assay.Its main units of measurement is DNA fragmentation index (DFI). A DFI of 20% or more significantly reduces the success rates after ICSI.DNA fragmentation was first documented by Williamson in 1970 when he observed discrete oligomeric fragments occurring during cell death in primary neonatal liver cultures. He described the cytoplasmic DNA isolated from mouse liver cells after culture was characterized by DNA fragments with a molecular weight consisting of multiples of 135 kDa. This finding was consistent with the hypothesis that these DNA fragments were a specific degradation product of nuclear DNA.".
- DNA_fragmentation thumbnail Complete_Histone_with_DNA.png?width=300.
- DNA_fragmentation wikiPageID "1822649".
- DNA_fragmentation wikiPageRevisionID "594833952".
- DNA_fragmentation hasPhotoCollection DNA_fragmentation.
- DNA_fragmentation subject Category:DNA.
- DNA_fragmentation comment "DNA fragmentation is the separation or breaking of DNA strands into pieces. It can be intentional by laboratory personnel or the cells, or it can be spontaneous. Spontaneous or accidental DNA fragmentation is fragmentation that gradually accumulates in a cell. It can be measured by e.g. Comet assay. The degree of DNA fragmentation can predict outcomes for in vitro fertilization (IVF) and its expansion intracytoplasmic sperm injection (ICSI).".
- DNA_fragmentation label "DNA fragmentation".
- DNA_fragmentation label "Frammentazione del DNA".
- DNA_fragmentation sameAs Frammentazione_del_DNA.
- DNA_fragmentation sameAs m.0cc5y88.
- DNA_fragmentation sameAs Q3749256.
- DNA_fragmentation sameAs Q3749256.
- DNA_fragmentation wasDerivedFrom DNA_fragmentation?oldid=594833952.
- DNA_fragmentation depiction Complete_Histone_with_DNA.png.
- DNA_fragmentation isPrimaryTopicOf DNA_fragmentation.
