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- DNA_machine abstract "A DNA machine is a molecular machine constructed from DNA. Research into DNA machines was pioneered in the late 1980s by Nadrian Seeman and co-workers from New York University. DNA is used because of the numerous biological tools already found in nature that can affect DNA, and the immense knowledge of how DNA works previously researched by biochemists.DNA machines can be logically designed since DNA assembly of the double helix is based on strict rules of base pairing that allow portions of the strand to be predictably connected based on their sequence. This 'selective stickiness' is a key advantage in the construction of DNA machines.An example of a DNA machine was reported by Bernard Yurke and co-workers at Lucent Technologies in the year 2000, who constructed molecular tweezers out of DNA.The DNA tweezers contain three strands: A, B and C. Strand A latches onto half of strand B and half of strand C, and so it joins them all together. Strand A acts as a hinge so that the two 'arms' — AB and AC — can move. The structure floats with its arms open wide. They can be pulled shut by adding a fourth strand of DNA (D) 'programmed' to stick to both of the dangling, unpaired sections of strands B and C. The closing of the tweezers was proven by tagging strand A at either end with light-emitting molecules that do not emit light when they are close together. To re-open the tweezers add a further strand (E) with the right sequence to pair up with strand D. Once paired up, they have no connection to the machine BAC, so float away. The DNA machine can be opened and closed repeatedly by cycling between strands D and E. These tweezers can be used for removing drugs from inside fullerenes as well as from a self assembled DNA tetrahedron. The state of the device can be determined by measuring the separation between donor and acceptor fluorophores using FRET.".
- DNA_machine wikiPageID "3293508".
- DNA_machine wikiPageRevisionID "591036338".
- DNA_machine hasPhotoCollection DNA_machine.
- DNA_machine subject Category:DNA_nanotechnology.
- DNA_machine subject Category:Molecular_machines.
- DNA_machine type Artifact100021939.
- DNA_machine type Device103183080.
- DNA_machine type Instrumentality103575240.
- DNA_machine type Machine103699975.
- DNA_machine type MolecularMachines.
- DNA_machine type Object100002684.
- DNA_machine type PhysicalEntity100001930.
- DNA_machine type Whole100003553.
- DNA_machine comment "A DNA machine is a molecular machine constructed from DNA. Research into DNA machines was pioneered in the late 1980s by Nadrian Seeman and co-workers from New York University.".
- DNA_machine label "DNA machine".
- DNA_machine label "DNA-Maschine".
- DNA_machine label "Macchina di DNA".
- DNA_machine label "ДНК-машина".
- DNA_machine label "آلة الحمض النووي".
- DNA_machine sameAs DNA-Maschine.
- DNA_machine sameAs Macchina_di_DNA.
- DNA_machine sameAs m.093vbv.
- DNA_machine sameAs Q2619033.
- DNA_machine sameAs Q2619033.
- DNA_machine sameAs DNA_machine.
- DNA_machine wasDerivedFrom DNA_machine?oldid=591036338.
- DNA_machine isPrimaryTopicOf DNA_machine.