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- DNA_sequencer abstract "A DNA sequencer is a scientific instrument used to automate the DNA sequencing process. Given a sample of DNA, a DNA sequencer is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine. The order of the DNA bases is reported as a text string, called a read. Some DNA sequencers can be also considered optical instruments as they analyze light signals originating from fluorochromes attached to nucleotides.The first automated DNA sequencer was introduced by Applied Biosystems in 1987. It used the Sanger sequencing method, a technology which formed the basis of the “first generation” of DNA sequencers and enabled the completion of the human genome project in 2001.The human genome project catalysed the development of cheaper, high throughput and more accurate platforms known as Next Generation Sequencers (NGS). These include the 454, SoLiD and Illumina DNA sequencing platforms. Next generation sequencing machines have increased the rate of DNA sequence substantially compared with previous Sanger methods. DNA samples can be prepared automatically in as little as 90 mins, while a human genome can be sequenced at 15 times coverage in a matter of days.More recent, third-generation DNA sequencers such as SMRT and Oxford Nanopore measure the addition of nucleotides to a single DNA molecule in real time.Because of limitations in DNA sequencer technology these reads are short compared to the length of a genome therefore the reads must be assembled into longer contigs. The data may also contain errors, caused by limitations in the DNA sequencing technique or by errors during PCR amplification. DNA sequencer manufacturers use a number of different methods to detect which DNA bases are present. The specific protocols applied in different sequencing platforms have an impact in the final data that is generated. Therefore, comparing data quality and cost across different technologies can be a daunting task. Each manufacturer provides their own ways to inform sequencing errors and scores. However, errors and scores between different platforms cannot always be compared directly. Since these systems rely on different DNA sequencing approaches, choosing the best DNA sequencer and method will typically depend on the experiment objectives and available budget.".
- DNA_sequencer thumbnail DNA-Sequencers_from_Flickr_57080968.jpg?width=300.
- DNA_sequencer wikiPageID "127511".
- DNA_sequencer wikiPageRevisionID "606812993".
- DNA_sequencer caption "DNA sequencers".
- DNA_sequencer hasPhotoCollection DNA_sequencer.
- DNA_sequencer manufacturers Beckman_Coulter.
- DNA_sequencer manufacturers Illumina_(company).
- DNA_sequencer manufacturers Life_Technologies_(Thermo_Fisher_Scientific).
- DNA_sequencer manufacturers Pacific_Biosciences.
- DNA_sequencer manufacturers Roche_Applied_Science.
- DNA_sequencer name "DNA Sequencer".
- DNA_sequencer subject Category:DNA_sequencing.
- DNA_sequencer subject Category:Molecular_biology.
- DNA_sequencer subject Category:Scientific_instruments.
- DNA_sequencer type Artifact100021939.
- DNA_sequencer type Device103183080.
- DNA_sequencer type Instrument103574816.
- DNA_sequencer type Instrumentality103575240.
- DNA_sequencer type Object100002684.
- DNA_sequencer type PhysicalEntity100001930.
- DNA_sequencer type ScientificInstrument104147495.
- DNA_sequencer type ScientificInstruments.
- DNA_sequencer type Whole100003553.
- DNA_sequencer comment "A DNA sequencer is a scientific instrument used to automate the DNA sequencing process. Given a sample of DNA, a DNA sequencer is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine. The order of the DNA bases is reported as a text string, called a read.".
- DNA_sequencer label "DNA sequencer".
- DNA_sequencer label "Sequenzierautomat".
- DNA_sequencer label "Séquenceur d'ADN".
- DNA_sequencer sameAs Sequenzierautomat.
- DNA_sequencer sameAs Séquenceur_d'ADN.
- DNA_sequencer sameAs m.025rsqk.
- DNA_sequencer sameAs Q908889.
- DNA_sequencer sameAs Q908889.
- DNA_sequencer sameAs DNA_sequencer.
- DNA_sequencer wasDerivedFrom DNA_sequencer?oldid=606812993.
- DNA_sequencer depiction DNA-Sequencers_from_Flickr_57080968.jpg.
- DNA_sequencer isPrimaryTopicOf DNA_sequencer.
