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- DUSP3 abstract "Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene.The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.".
- DUSP3 entrezgene "1845".
- DUSP3 wikiPageID "14817162".
- DUSP3 wikiPageRevisionID "591118943".
- DUSP3 hasPhotoCollection DUSP3.
- DUSP3 requireManualInspection "no".
- DUSP3 summaryText "The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein kinase superfamily , which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.".
- DUSP3 updateCitations "yes".
- DUSP3 updatePage "yes".
- DUSP3 updateProteinBox "yes".
- DUSP3 updateSummary "yes".
- DUSP3 subject Category:Genes_mutated_in_mice.
- DUSP3 type Biomolecule.
- DUSP3 type Protein.
- DUSP3 type BiologicalObject.
- DUSP3 comment "Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene.The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.".
- DUSP3 label "DUSP3".
- DUSP3 label "DUSP3".
- DUSP3 sameAs DUSP3.
- DUSP3 sameAs m.03gyz1g.
- DUSP3 sameAs Q5206319.
- DUSP3 sameAs Q5206319.
- DUSP3 wasDerivedFrom DUSP3?oldid=591118943.
- DUSP3 isPrimaryTopicOf DUSP3.