Matches in DBpedia 2014 for { <http://dbpedia.org/resource/DUSP4> ?p ?o. }
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- DUSP4 abstract "Dual specificity protein phosphatase 4 is an enzyme that in humans is encoded by the DUSP4 gene.The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.In melanocytic cells DUSP4 gene expression may be regulated by MITF.".
- DUSP4 entrezgene "1846".
- DUSP4 wikiPageID "14879876".
- DUSP4 wikiPageRevisionID "591118974".
- DUSP4 hasPhotoCollection DUSP4.
- DUSP4 requireManualInspection "no".
- DUSP4 summaryText "The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein kinase superfamily , which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. In melanocytic cells DUSP4 gene expression may be regulated by MITF.".
- DUSP4 updateCitations "yes".
- DUSP4 updatePage "yes".
- DUSP4 updateProteinBox "yes".
- DUSP4 updateSummary "yes".
- DUSP4 type Biomolecule.
- DUSP4 type Protein.
- DUSP4 type BiologicalObject.
- DUSP4 comment "Dual specificity protein phosphatase 4 is an enzyme that in humans is encoded by the DUSP4 gene.The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.".
- DUSP4 label "DUSP4".
- DUSP4 sameAs m.03h03wy.
- DUSP4 sameAs Q5206318.
- DUSP4 sameAs Q5206318.
- DUSP4 wasDerivedFrom DUSP4?oldid=591118974.
- DUSP4 isPrimaryTopicOf DUSP4.