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- DUTP_diphosphatase abstract "In enzymology, a dUTP diphosphatase (EC 3.6.1.23) is an enzyme that catalyzes the chemical reactiondUTP + H2O dUMP + diphosphateThus, the two substrates of this enzyme are dUTP and H2O, whereas its two products are dUMP and diphosphate.This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dUTP nucleotidohydrolase. Other names in common use include deoxyuridine-triphosphatase, dUTPase, dUTP pyrophosphatase, desoxyuridine 5'-triphosphate nucleotidohydrolase, and desoxyuridine 5'-triphosphatase. This enzyme participates in pyrimidine metabolism.This enzyme has a dual function: on one hand, it removes dUTP from the deoxynucleotide pool, which reduces the probability of this base being incorporated into DNA by DNA polymerases, while on the other hand, it produces the dTTP precursor dUMP. Lack or inhibition of dUTPase action leads to harmful perturbations in the nucleotide pool resulting in increased uracil content of DNA that activates a hyperactive futile cycle of DNA repair.".
- DUTP_diphosphatase ecNumber "3.6.1.23".
- DUTP_diphosphatase thumbnail PDB_1f7o_EBI.jpg?width=300.
- DUTP_diphosphatase wikiPageID "14440452".
- DUTP_diphosphatase wikiPageRevisionID "591119804".
- DUTP_diphosphatase caption "crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three crystal forms.".
- DUTP_diphosphatase caption "the crystal structure of a complex of campylobacter jejuni dutpase with substrate analogue dupnhp".
- DUTP_diphosphatase casNumber "37289".
- DUTP_diphosphatase ecNumber "3.6".
- DUTP_diphosphatase goCode "4170".
- DUTP_diphosphatase hasPhotoCollection DUTP_diphosphatase.
- DUTP_diphosphatase interpro "IPR008180".
- DUTP_diphosphatase interpro "IPR014871".
- DUTP_diphosphatase iubmbEcNumber "3".
- DUTP_diphosphatase name "dUTP diphosphatase".
- DUTP_diphosphatase name "dUTPase".
- DUTP_diphosphatase name "dUTPase_2".
- DUTP_diphosphatase pfam "PF00692".
- DUTP_diphosphatase pfam "PF08761".
- DUTP_diphosphatase pfamClan "CL0153".
- DUTP_diphosphatase pfamClan "CL0231".
- DUTP_diphosphatase scop "1".
- DUTP_diphosphatase scop "6.31152E7".
- DUTP_diphosphatase symbol "dUTPase".
- DUTP_diphosphatase symbol "dUTPase_2".
- DUTP_diphosphatase subject Category:EC_3.6.1.
- DUTP_diphosphatase subject Category:Enzymes_of_known_structure.
- DUTP_diphosphatase type Abstraction100002137.
- DUTP_diphosphatase type Activator114723079.
- DUTP_diphosphatase type Catalyst114723628.
- DUTP_diphosphatase type Chemical114806838.
- DUTP_diphosphatase type Compound114818238.
- DUTP_diphosphatase type Enzyme114732946.
- DUTP_diphosphatase type EnzymesOfKnownStructure.
- DUTP_diphosphatase type Macromolecule114944888.
- DUTP_diphosphatase type Material114580897.
- DUTP_diphosphatase type Matter100020827.
- DUTP_diphosphatase type Molecule114682133.
- DUTP_diphosphatase type OrganicCompound114727670.
- DUTP_diphosphatase type Part113809207.
- DUTP_diphosphatase type PhysicalEntity100001930.
- DUTP_diphosphatase type Protein114728724.
- DUTP_diphosphatase type Relation100031921.
- DUTP_diphosphatase type Substance100019613.
- DUTP_diphosphatase type Thing100002452.
- DUTP_diphosphatase type Unit109465459.
- DUTP_diphosphatase type Biomolecule.
- DUTP_diphosphatase type Enzyme.
- DUTP_diphosphatase type BiologicalObject.
- DUTP_diphosphatase comment "In enzymology, a dUTP diphosphatase (EC 3.6.1.23) is an enzyme that catalyzes the chemical reactiondUTP + H2O dUMP + diphosphateThus, the two substrates of this enzyme are dUTP and H2O, whereas its two products are dUMP and diphosphate.This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dUTP nucleotidohydrolase.".
- DUTP_diphosphatase label "DUTP diphosphatase".
- DUTP_diphosphatase sameAs m.03d3m6_.
- DUTP_diphosphatase sameAs Q5206324.
- DUTP_diphosphatase sameAs Q5206324.
- DUTP_diphosphatase sameAs 5255.
- DUTP_diphosphatase sameAs DUTP_diphosphatase.
- DUTP_diphosphatase wasDerivedFrom DUTP_diphosphatase?oldid=591119804.
- DUTP_diphosphatase depiction PDB_1f7o_EBI.jpg.
- DUTP_diphosphatase isPrimaryTopicOf DUTP_diphosphatase.
- DUTP_diphosphatase name "dUTP diphosphatase".
