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- De_novo_protein_structure_prediction abstract "In computational biology, de novo protein structure prediction refers to an algorithmic process by which protein tertiary structure is predicted from its amino acid primary sequence. The problem itself has occupied leading scientists for decades while still remaining unsolved. According to Science, the problem remains one of the top 125 outstanding issues in modern science. At present, some of the most successful methods have a reasonable probability of predicting the folds of small, single-domain proteins within 1.5 angstroms over the entire structure.De novo methods tend to require vast computational resources, and have thus only been carried out for relatively small proteins. De novo protein structure modeling is distinguished from Template-based modeling (TBM) by the fact that no solved homolog to the protein of interest is known, making efforts to predict protein structure from amino acid sequence exceedingly difficult. Prediction of protein structure de novo for larger proteins will require better algorithms and larger computational resources such as those afforded by either powerful supercomputers (such as Blue Gene or MDGRAPE-3) or distributed computing projects (such as Folding@home, Rosetta@home, the Human Proteome Folding Project, or Nutritious Rice for the World). Although computational barriers are vast, the potential benefits of structural genomics (by predicted or experimental methods) to fields such as medicine and drug design make de novo structure prediction an active research field.".
- De_novo_protein_structure_prediction wikiPageExternalLink expasy.org.
- De_novo_protein_structure_prediction wikiPageExternalLink portal.
- De_novo_protein_structure_prediction wikiPageExternalLink folding.stanford.edu.
- De_novo_protein_structure_prediction wikiPageExternalLink predictioncenter.org.
- De_novo_protein_structure_prediction wikiPageExternalLink swissprot.
- De_novo_protein_structure_prediction wikiPageExternalLink pdb.
- De_novo_protein_structure_prediction wikiPageExternalLink viewHpf2Research.do.
- De_novo_protein_structure_prediction wikiPageID "9378673".
- De_novo_protein_structure_prediction wikiPageRevisionID "596548810".
- De_novo_protein_structure_prediction hasPhotoCollection De_novo_protein_structure_prediction.
- De_novo_protein_structure_prediction subject Category:Bioinformatics.
- De_novo_protein_structure_prediction subject Category:Protein_methods.
- De_novo_protein_structure_prediction subject Category:Protein_structure.
- De_novo_protein_structure_prediction type Ability105616246.
- De_novo_protein_structure_prediction type Abstraction100002137.
- De_novo_protein_structure_prediction type Cognition100023271.
- De_novo_protein_structure_prediction type Know-how105616786.
- De_novo_protein_structure_prediction type Method105660268.
- De_novo_protein_structure_prediction type ProteinMethods.
- De_novo_protein_structure_prediction type PsychologicalFeature100023100.
- De_novo_protein_structure_prediction comment "In computational biology, de novo protein structure prediction refers to an algorithmic process by which protein tertiary structure is predicted from its amino acid primary sequence. The problem itself has occupied leading scientists for decades while still remaining unsolved. According to Science, the problem remains one of the top 125 outstanding issues in modern science.".
- De_novo_protein_structure_prediction label "De novo protein structure prediction".
- De_novo_protein_structure_prediction sameAs m.0286hxn.
- De_novo_protein_structure_prediction sameAs Q5244958.
- De_novo_protein_structure_prediction sameAs Q5244958.
- De_novo_protein_structure_prediction sameAs De_novo_protein_structure_prediction.
- De_novo_protein_structure_prediction wasDerivedFrom De_novo_protein_structure_prediction?oldid=596548810.
- De_novo_protein_structure_prediction isPrimaryTopicOf De_novo_protein_structure_prediction.