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- Death_domain abstract "The death domain (DD) is a protein interaction module composed of a bundle of six alpha-helices. DD is a subclass of protein motif known as the death fold and is related in sequence and structure to the death effector domain (DED) and the caspase recruitment domain (CARD), which work in similar pathways and show similar interaction properties. DD bind each other forming oligomers. Mammals have numerous and diverse DD-containing proteins. Within these proteins, the DD domains can be found in combination with other domains, including: CARDs, DEDs, ankyrin repeats, caspase-like folds, kinase domains, leucine zippers, leucine-rich repeats (LRR), TIR domains, and ZU5 domains.Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB, which typically involves interactions with TNF (tumour necrosis factor) cytokine receptors. In humans, eight of the over 30 known TNF receptors contain DD in their cytoplasmic tails; several of these TNF receptors use caspase activation as a signaling mechanism. The DD mediates self-association of these receptors, thus giving the signal to downstream events that lead to apoptosis. Other DD-containing proteins, such as ankyrin, MyD88 and pelle, are probably not directly involved in cell death signalling. DD-containing proteins also have links to innate immunity, communicating with Toll-like receptors through bipartite adapter proteins such as MyD88.".
- Death_domain symbol "Death".
- Death_domain thumbnail PDB_1ddf_EBI.jpg?width=300.
- Death_domain wikiPageID "24235232".
- Death_domain wikiPageRevisionID "590955872".
- Death_domain caption "Structure of the Fas death domain.".
- Death_domain cdd "cd01670".
- Death_domain hasPhotoCollection Death_domain.
- Death_domain interpro "IPR000488".
- Death_domain name "Death domain".
- Death_domain pdb ", , , , , , , , , , , , ,".
- Death_domain pfam "PF00531".
- Death_domain prosite "PDOC50017".
- Death_domain scop "1".
- Death_domain smart "DEATH".
- Death_domain symbol "Death".
- Death_domain subject Category:Protein_domains.
- Death_domain type Abstraction100002137.
- Death_domain type Attribute100024264.
- Death_domain type Environment113934596.
- Death_domain type ProteinDomains.
- Death_domain type Situation113927383.
- Death_domain type Sphere114514039.
- Death_domain type State100024720.
- Death_domain type Biomolecule.
- Death_domain type Protein.
- Death_domain type BiologicalObject.
- Death_domain comment "The death domain (DD) is a protein interaction module composed of a bundle of six alpha-helices. DD is a subclass of protein motif known as the death fold and is related in sequence and structure to the death effector domain (DED) and the caspase recruitment domain (CARD), which work in similar pathways and show similar interaction properties. DD bind each other forming oligomers. Mammals have numerous and diverse DD-containing proteins.".
- Death_domain label "Death domain".
- Death_domain sameAs m.07kdms6.
- Death_domain sameAs Q5247322.
- Death_domain sameAs Q5247322.
- Death_domain sameAs Death_domain.
- Death_domain wasDerivedFrom Death_domain?oldid=590955872.
- Death_domain depiction PDB_1ddf_EBI.jpg.
- Death_domain isPrimaryTopicOf Death_domain.
