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- Death_effector_domain abstract "The death-effector domain (DED) is a protein interaction domain found to regulate a variety of cellular signalling pathways. The DED domain is found in inactive procaspases (cysteine proteases) and proteins that regulate caspase activation in the apoptosis cascade such as FAS-associating death domain-containing protein (FADD). FADD recruits procaspase 8 and procaspase 10 into a death induced signaling complex (DISC). This recruitment is mediated by a homotypic interaction between the procaspase DED and a second DED that is death effector domain in an adaptor protein that is directly associated with activated TNF receptors. Complex formation allows proteolytic activation of procaspase into the active caspase form which results in the initiation of apoptosis (cell death). Structurally the DED domain are a subclass of protein motif known as the death fold and contains 6 alpha helices, that closely resemble the structure of the Death domain.".
- Death_effector_domain symbol "DED".
- Death_effector_domain thumbnail PDB_1a1z_EBI.jpg?width=300.
- Death_effector_domain wikiPageExternalLink index.php?option=com_content&task=view&id=32&Itemid=29.
- Death_effector_domain wikiPageID "2646715".
- Death_effector_domain wikiPageRevisionID "590955924".
- Death_effector_domain caption "structure of the FADD death-effector domain.".
- Death_effector_domain cdd "cd00045".
- Death_effector_domain hasPhotoCollection Death_effector_domain.
- Death_effector_domain interpro "IPR001875".
- Death_effector_domain name "Death effector domain".
- Death_effector_domain pdb ", , , , ,".
- Death_effector_domain pfam "PF01335".
- Death_effector_domain prosite "PS50168".
- Death_effector_domain scop "1".
- Death_effector_domain smart "DED".
- Death_effector_domain symbol "DED".
- Death_effector_domain subject Category:Protein_domains.
- Death_effector_domain type Abstraction100002137.
- Death_effector_domain type Attribute100024264.
- Death_effector_domain type Environment113934596.
- Death_effector_domain type ProteinDomains.
- Death_effector_domain type Situation113927383.
- Death_effector_domain type Sphere114514039.
- Death_effector_domain type State100024720.
- Death_effector_domain type Biomolecule.
- Death_effector_domain type Protein.
- Death_effector_domain type BiologicalObject.
- Death_effector_domain comment "The death-effector domain (DED) is a protein interaction domain found to regulate a variety of cellular signalling pathways. The DED domain is found in inactive procaspases (cysteine proteases) and proteins that regulate caspase activation in the apoptosis cascade such as FAS-associating death domain-containing protein (FADD). FADD recruits procaspase 8 and procaspase 10 into a death induced signaling complex (DISC).".
- Death_effector_domain label "Death effector domain".
- Death_effector_domain sameAs m.07v3c_.
- Death_effector_domain sameAs Q5247330.
- Death_effector_domain sameAs Q5247330.
- Death_effector_domain sameAs Death_effector_domain.
- Death_effector_domain wasDerivedFrom Death_effector_domain?oldid=590955924.
- Death_effector_domain depiction PDB_1a1z_EBI.jpg.
- Death_effector_domain isPrimaryTopicOf Death_effector_domain.
