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- Degron abstract "A degron is a specific sequence of amino acids in a protein that directs the starting place of degradation. A degron sequence can occur at either the N or C-terminal region, these are called N-Degrons or C-degrons respectively.A temperature sensitive degron takes advantage of the N-end rule pathway, in which a destabilizing N-terminal residue dramatically decreases the in vivo half-life of a protein. The degron is a fusion protein of ubiquitin, arginine, and DHFR. DHFR is dihydrofolate reductase, a mouse-derived enzyme that functions in the synthesis of thymine. It is also heat-labile - at a higher temperature of 37°C, becomes slightly unfolded and exposes an internal lysine, the site of poly-ubiquitination. Proteolysis is highly processive, and the protein is degraded by the proteasome. The degron can be fused to a gene to produce the corresponding temperature-sensitive protein. It is portable, and can be transferred on a plasmid.A ligand controllable degron takes advantage of a mutant form of FKBP12 protein that can be controlled using a synthetic ligand. Small molecule Shield1 binds specifically to the degron making it inactive. An inactive degron no longer promotes protein degradation. The degron is reactivated when the small molecule is removed by washing the cells and active protein degradation occurs through proteasome mediated proteolysis.".
- Degron wikiPageID "6313310".
- Degron wikiPageRevisionID "600034186".
- Degron hasPhotoCollection Degron.
- Degron subject Category:Amino_acids.
- Degron type Abstraction100002137.
- Degron type AminoAcid114601829.
- Degron type AminoAcids.
- Degron type Chemical114806838.
- Degron type Compound114818238.
- Degron type Material114580897.
- Degron type Matter100020827.
- Degron type OrganicCompound114727670.
- Degron type Part113809207.
- Degron type PhysicalEntity100001930.
- Degron type Relation100031921.
- Degron type Substance100019613.
- Degron comment "A degron is a specific sequence of amino acids in a protein that directs the starting place of degradation. A degron sequence can occur at either the N or C-terminal region, these are called N-Degrons or C-degrons respectively.A temperature sensitive degron takes advantage of the N-end rule pathway, in which a destabilizing N-terminal residue dramatically decreases the in vivo half-life of a protein. The degron is a fusion protein of ubiquitin, arginine, and DHFR.".
- Degron label "Degron".
- Degron sameAs m.0g0mrz.
- Degron sameAs Q5251856.
- Degron sameAs Q5251856.
- Degron sameAs Degron.
- Degron wasDerivedFrom Degron?oldid=600034186.
- Degron isPrimaryTopicOf Degron.