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- Desmoplakin abstract "Desmoplakin is a protein associated with desmosomes.Desmoplakin is a protein in humans that is encoded by the DSP gene.Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. This is further sub divided into a region called the "Plakin domain" made up of repetitive domains called Spectrin repeats. A crystal structure of part of the plakin domain has been resolved, while the entire plakin domain has been elucidated using Small angle X-ray scattering which revealed a non-linear structure, an unexpected result considering spectrin repeats are observed in linear orientations. The C-terminus of desmoplakin binds with intermediate filaments. These are further sub divided to three homologous Plakin repeat domains (see PDBs below). In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.".
- Desmoplakin entrezgene "1832".
- Desmoplakin thumbnail Desmosome.gif?width=300.
- Desmoplakin wikiPageExternalLink NBK1131.
- Desmoplakin wikiPageExternalLink 604772,605676,601214,107970,125645,125647,125671,173325,180902,190230,600996,602086,602087,602861,604400,604401,607450,609040,609160,610193,610476,611528,612048,107970,125645,125647,125671,173325,180902,190230,600996,602086,602087,602861,604400,604401,607450,609040,609160,610193,610476,611528,612048.
- Desmoplakin wikiPageID "7105107".
- Desmoplakin wikiPageRevisionID "602334086".
- Desmoplakin hasPhotoCollection Desmoplakin.
- Desmoplakin requireManualInspection "no".
- Desmoplakin summaryText "Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. This is further sub divided into a region called the "Plakin domain" made up of repetitive domains called Spectrin repeats. A crystal structure of part of the plakin domain has been resolved, while the entire plakin domain has been elucidated using Small angle X-ray scattering which revealed a non-linear structure, an unexpected result considering spectrin repeats are observed in linear orientations.".
- Desmoplakin updateCitations "yes".
- Desmoplakin updatePage "yes".
- Desmoplakin updateProteinBox "yes".
- Desmoplakin updateSummary "yes".
- Desmoplakin subject Category:Proteins.
- Desmoplakin type Abstraction100002137.
- Desmoplakin type Chemical114806838.
- Desmoplakin type Compound114818238.
- Desmoplakin type Macromolecule114944888.
- Desmoplakin type Material114580897.
- Desmoplakin type Matter100020827.
- Desmoplakin type Molecule114682133.
- Desmoplakin type OrganicCompound114727670.
- Desmoplakin type Part113809207.
- Desmoplakin type PhysicalEntity100001930.
- Desmoplakin type Protein114728724.
- Desmoplakin type Proteins.
- Desmoplakin type Relation100031921.
- Desmoplakin type Substance100019613.
- Desmoplakin type Thing100002452.
- Desmoplakin type Unit109465459.
- Desmoplakin type Biomolecule.
- Desmoplakin type Protein.
- Desmoplakin type BiologicalObject.
- Desmoplakin comment "Desmoplakin is a protein associated with desmosomes.Desmoplakin is a protein in humans that is encoded by the DSP gene.Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin.".
- Desmoplakin label "Desmoplakin".
- Desmoplakin label "Desmoplakin".
- Desmoplakin sameAs Desmoplakin.
- Desmoplakin sameAs m.0h4blg.
- Desmoplakin sameAs Q5264821.
- Desmoplakin sameAs Q5264821.
- Desmoplakin sameAs Desmoplakin.
- Desmoplakin wasDerivedFrom Desmoplakin?oldid=602334086.
- Desmoplakin depiction Desmosome.gif.
- Desmoplakin isPrimaryTopicOf Desmoplakin.
