Matches in DBpedia 2014 for { <http://dbpedia.org/resource/DiFMDA> ?p ?o. }
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- DiFMDA abstract "Difluoromethylenedioxyamphetamine (DiFMDA) is a substituted derivative of methylenedioxyamphetamine (MDA), which was developed by Daniel Trachsel and coworkers, along with the corresponding fluorinated derivatives of MDMA, MDEA, BDB and MBDB, with the aim of finding a non-neurotoxic drug able to be used as a less harmful substitute for entactogenic drugs such as MDMA. Since a major route of the normal metabolism of these compounds is scission of the methylenedioxy ring, producing neurotoxic metabolites such as alpha-methyldopamine, it was hoped that the difluoromethylenedioxy bioisostere would show increased metabolic stability and less toxicity.These compounds have not yet been tested in animals to verify whether they show similar pharmacological activity to the non-fluorinated parent compounds, although in vitro binding studies show DFMDA to have a SERT affinity in between that of MDA and MDMA. However there is known to be a lack of bulk tolerance at this position of the molecule, shown by the generally reduced activity of the ethylidenedioxy and isopropylidenedioxy analogues. It is also now generally accepted that MDMA neurotoxicity results from a variety of different causes and is not solely due to accumulation of alpha-methyldopamine, making it unclear how much less neurotoxic DFMDA and related drugs would be in practice.".
- DiFMDA atcPrefix "none".
- DiFMDA casNumber "910393-51-0".
- DiFMDA iupacName "1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)propan-2-amine".
- DiFMDA thumbnail DFMDA.svg?width=300.
- DiFMDA wikiPageID "31366022".
- DiFMDA wikiPageRevisionID "591008984".
- DiFMDA atcPrefix "none".
- DiFMDA c "10".
- DiFMDA casNumber "910393".
- DiFMDA chemspiderid "26495356".
- DiFMDA f "2".
- DiFMDA h "11".
- DiFMDA hasPhotoCollection DiFMDA.
- DiFMDA inchi "1".
- DiFMDA inchikey "BHDXKBALNFHXDV-UHFFFAOYAR".
- DiFMDA iupacName "1".
- DiFMDA molecularWeight "215.076".
- DiFMDA n "1".
- DiFMDA o "2".
- DiFMDA smiles "CCN".
- DiFMDA stdinchi "1".
- DiFMDA stdinchikey "BHDXKBALNFHXDV-UHFFFAOYSA-N".
- DiFMDA verifiedfields "changed".
- DiFMDA verifiedrevid "451607745".
- DiFMDA subject Category:Amphetamines.
- DiFMDA type Agent114778436.
- DiFMDA type Amphetamine102704153.
- DiFMDA type Amphetamines.
- DiFMDA type CausalAgent100007347.
- DiFMDA type Drug103247620.
- DiFMDA type DrugOfAbuse103248958.
- DiFMDA type Matter100020827.
- DiFMDA type PhysicalEntity100001930.
- DiFMDA type Stimulant104320126.
- DiFMDA type Substance100020090.
- DiFMDA type Drug.
- DiFMDA type FunctionalSubstance.
- DiFMDA comment "Difluoromethylenedioxyamphetamine (DiFMDA) is a substituted derivative of methylenedioxyamphetamine (MDA), which was developed by Daniel Trachsel and coworkers, along with the corresponding fluorinated derivatives of MDMA, MDEA, BDB and MBDB, with the aim of finding a non-neurotoxic drug able to be used as a less harmful substitute for entactogenic drugs such as MDMA.".
- DiFMDA label "DiFMDA".
- DiFMDA sameAs m.0gl00b2.
- DiFMDA sameAs Q5269984.
- DiFMDA sameAs Q5269984.
- DiFMDA sameAs DiFMDA.
- DiFMDA wasDerivedFrom DiFMDA?oldid=591008984.
- DiFMDA depiction DFMDA.svg.
- DiFMDA isPrimaryTopicOf DiFMDA.
