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- Diabetic_foot_ulcer abstract "Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of the diabetic foot. It occurs in 15% of all patients with diabetes and precedes 84% of all lower leg amputations. Major increase in mortality among diabetic patients, observed over the past 20 years is considered to be due to the development of macro and micro vascular complications, including failure of the wound healing process.[citation needed] Wound healing is an innate mechanism of action that works reliably most of the time. A key feature of wound healing is stepwise repair of lost extracellular matrix (ECM) that forms the largest component of the dermal skin layer. Controlled and accurate rebuilding is essential to avoid under- or over-healing that may lead to various abnormalities. But in some cases, certain disorders or physiological insult disturbs the wound healing process. Diabetes mellitus is one such metabolic disorder that impedes the normal steps of the wound healing process. Many histopathological studies show a prolonged inflammatory phase in diabetic wounds, which causes a delay in the formation of mature granulation tissue and a parallel reduction in wound tensile strength.Non-healing chronic diabetic ulcers are often treated with extracellular matrix replacement therapy. So far, it is a common trend in diabetic foot care domain to use advanced moist wound therapy, bio-engineered tissue or skin substitute, growth factors and negative pressure wound therapy. No therapy is completely perfect as each type suffers from its own disadvantages.Moist wound therapy is known to promote fibroblast and keratinocyte proliferation and migration, collagen synthesis, early angiogenesis and wound contraction. At present, there are various categories of moist dressings available such as adhesive backing film, silicone coated foam, hydrogels, hydrocolloids etc. Unfortunately, all moist dressings cause fluid retention; most of them require secondary dressing and hence are not the best choice for exudative wounds. To address the physiological deficiencies underlying diabetic ulcer, various tissue engineering technologies have come up with cellular as well as acellular skin replacement products. New therapies in development are also promising, such as platelet rich fibrin wound patch therapy, which is often simpler and proving effective in chronic diabetic foot ulcers.".
- Diabetic_foot_ulcer thumbnail Neuropathic_heel_ulcer_diabetic.jpg?width=300.
- Diabetic_foot_ulcer wikiPageExternalLink diabetic-foot.net.
- Diabetic_foot_ulcer wikiPageExternalLink diabeticfootonline.blogspot.com.
- Diabetic_foot_ulcer wikiPageExternalLink diabeticfoot.
- Diabetic_foot_ulcer wikiPageExternalLink www.dfsg.org.
- Diabetic_foot_ulcer wikiPageExternalLink 5164.
- Diabetic_foot_ulcer wikiPageID "4301982".
- Diabetic_foot_ulcer wikiPageRevisionID "606359500".
- Diabetic_foot_ulcer hasPhotoCollection Diabetic_foot_ulcer.
- Diabetic_foot_ulcer subject Category:Diabetes.
- Diabetic_foot_ulcer comment "Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of the diabetic foot. It occurs in 15% of all patients with diabetes and precedes 84% of all lower leg amputations.".
- Diabetic_foot_ulcer label "Diabetic foot ulcer".
- Diabetic_foot_ulcer label "Mal perforant plantaire".
- Diabetic_foot_ulcer label "Ulcera diabetica".
- Diabetic_foot_ulcer sameAs Mal_perforant_plantaire.
- Diabetic_foot_ulcer sameAs Ulcera_diabetica.
- Diabetic_foot_ulcer sameAs m.064p1q4.
- Diabetic_foot_ulcer sameAs Q52859.
- Diabetic_foot_ulcer sameAs Q52859.
- Diabetic_foot_ulcer wasDerivedFrom Diabetic_foot_ulcer?oldid=606359500.
- Diabetic_foot_ulcer depiction Neuropathic_heel_ulcer_diabetic.jpg.
- Diabetic_foot_ulcer isPrimaryTopicOf Diabetic_foot_ulcer.
