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- Dihydrofolate_reductase abstract "Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene.It is found in the q11→q22 region of chromosome 5.Bacterial species possesses distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar. The plasmid-encoded DHFR (R67 dihydrofolate reductase) shows a high level of resistance to the antibiotic trimethoprim. It is a homotetramer with an unusual pore, which contains the active site, passing through the middle of the molecule. Its structure is unrelated to that of chromosomal DHFRs.".
- Dihydrofolate_reductase ecNumber "1.5.1.3".
- Dihydrofolate_reductase thumbnail PDB_8dfr_EBI.jpg?width=300.
- Dihydrofolate_reductase wikiPageExternalLink Dihydrofolate_reductase.
- Dihydrofolate_reductase wikiPageExternalLink hitchings-lecture.pdf.
- Dihydrofolate_reductase wikiPageID "102575".
- Dihydrofolate_reductase wikiPageRevisionID "606572682".
- Dihydrofolate_reductase caption "Crystal structure of chicken liver dihydrofolate reductase. PDB entry".
- Dihydrofolate_reductase caption "High-resolution structure of a plasmid-encoded dihydrofolate reductase from E.coli. PDB entry".
- Dihydrofolate_reductase casNumber "9002-03-03".
- Dihydrofolate_reductase ecNumber "1.5".
- Dihydrofolate_reductase goCode "4146".
- Dihydrofolate_reductase hasPhotoCollection Dihydrofolate_reductase.
- Dihydrofolate_reductase interpro "IPR001796".
- Dihydrofolate_reductase interpro "IPR009159".
- Dihydrofolate_reductase iubmbEcNumber "1".
- Dihydrofolate_reductase name "Dihydrofolate reductase".
- Dihydrofolate_reductase name "R67 dihydrofolate reductase".
- Dihydrofolate_reductase pfam "PF00186".
- Dihydrofolate_reductase pfam "PF06442".
- Dihydrofolate_reductase pfamClan "CL0387".
- Dihydrofolate_reductase prosite "PDOC00072".
- Dihydrofolate_reductase scop "1".
- Dihydrofolate_reductase symbol "DHFR_1".
- Dihydrofolate_reductase symbol "DHFR_2".
- Dihydrofolate_reductase subject Category:EC_1.5.1.
- Dihydrofolate_reductase subject Category:Protein_domains.
- Dihydrofolate_reductase type Abstraction100002137.
- Dihydrofolate_reductase type Activator114723079.
- Dihydrofolate_reductase type Attribute100024264.
- Dihydrofolate_reductase type Catalyst114723628.
- Dihydrofolate_reductase type Chemical114806838.
- Dihydrofolate_reductase type Compound114818238.
- Dihydrofolate_reductase type Environment113934596.
- Dihydrofolate_reductase type Enzyme114732946.
- Dihydrofolate_reductase type Enzymes.
- Dihydrofolate_reductase type Macromolecule114944888.
- Dihydrofolate_reductase type Material114580897.
- Dihydrofolate_reductase type Matter100020827.
- Dihydrofolate_reductase type Molecule114682133.
- Dihydrofolate_reductase type OrganicCompound114727670.
- Dihydrofolate_reductase type Part113809207.
- Dihydrofolate_reductase type PhysicalEntity100001930.
- Dihydrofolate_reductase type Protein114728724.
- Dihydrofolate_reductase type ProteinDomains.
- Dihydrofolate_reductase type Relation100031921.
- Dihydrofolate_reductase type Situation113927383.
- Dihydrofolate_reductase type Sphere114514039.
- Dihydrofolate_reductase type State100024720.
- Dihydrofolate_reductase type Substance100019613.
- Dihydrofolate_reductase type Thing100002452.
- Dihydrofolate_reductase type Unit109465459.
- Dihydrofolate_reductase type Biomolecule.
- Dihydrofolate_reductase type Enzyme.
- Dihydrofolate_reductase type BiologicalObject.
- Dihydrofolate_reductase comment "Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene.It is found in the q11→q22 region of chromosome 5.Bacterial species possesses distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar.".
- Dihydrofolate_reductase label "Dihidrofolato reductasa".
- Dihydrofolate_reductase label "Dihydrofolate reductase".
- Dihydrofolate_reductase label "Dihydrofolate réductase".
- Dihydrofolate_reductase label "Dihydrofolatreduktase".
- Dihydrofolate_reductase label "Diidrofolato reduttasi".
- Dihydrofolate_reductase label "Дигидрофолатредуктаза".
- Dihydrofolate_reductase label "اختزال ثنائي هيدروالفولات".
- Dihydrofolate_reductase label "ジヒドロ葉酸レダクターゼ".
- Dihydrofolate_reductase label "二氢叶酸还原酶".
- Dihydrofolate_reductase sameAs Dihydrofolatreduktase.
- Dihydrofolate_reductase sameAs Dihidrofolato_reductasa.
- Dihydrofolate_reductase sameAs Dihydrofolate_réductase.
- Dihydrofolate_reductase sameAs Diidrofolato_reduttasi.
- Dihydrofolate_reductase sameAs ジヒドロ葉酸レダクターゼ.
- Dihydrofolate_reductase sameAs DHFR.
- Dihydrofolate_reductase sameAs m.0pys4.
- Dihydrofolate_reductase sameAs Q417149.
- Dihydrofolate_reductase sameAs Q417149.
- Dihydrofolate_reductase sameAs 2381.
- Dihydrofolate_reductase sameAs 2833.
- Dihydrofolate_reductase sameAs 2931.
- Dihydrofolate_reductase sameAs 3544.
- Dihydrofolate_reductase sameAs 365.
- Dihydrofolate_reductase sameAs 3682.
- Dihydrofolate_reductase sameAs 5465.
- Dihydrofolate_reductase sameAs Dihydrofolate_reductase.
- Dihydrofolate_reductase wasDerivedFrom Dihydrofolate_reductase?oldid=606572682.
- Dihydrofolate_reductase depiction PDB_8dfr_EBI.jpg.
- Dihydrofolate_reductase isPrimaryTopicOf Dihydrofolate_reductase.
- Dihydrofolate_reductase name "Dihydrofolate reductase".