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- Dio3_Gene abstract "The Dio3 gene codes for type 3 iodothyronine deiodinase (D3), an enzyme that inactivates thyroid hormones and is highly expressed throughout fetal development, peaking early and decreasing towards the end of gestation. Part of the Dlk1-Dio3 imprinting control region, this gene is one involved in the epigenetic process that causes a subset of genes to be regulated based on their parental origin (see Genomic Imprinting). Such imprinted genes are required for the formation of the placenta as well as the development of cellular lineages such as those derived from the mesoderm and ectoderm. D3 is found in the pregnant uterus, placenta, and mammalian fetal tissues where it is thought to be involved in the transfer of thyroid hormone between the mother and fetus. Expression of D3 contributes to the development of the brain, skin, liver, bone, ovary, testis, intestine, and brown adipose tissue. Introductory observations of D3-deficient mice indicate growth retardation and even some neonatal death. Due to its ability to activate or inactivate thyroid hormone, Dio3 coding of D3 could be a target for therapeutic intervention in insulin-related illness such as diabetes. In addition, an abnormal amount of Dio3 related to insufficient thyroid hormone levels could be responsible for the disruption of brain development in conjunction with alcohol exposure. Many factors modify genetic imprinting of Dio3, making it a potential aid in understanding prenatal insults and their production of spectrum disorders.The gene was mapped to chromosome 14q32 using fluorescence in situ hybridization (FISH) in 1998.".
- Dio3_Gene ecNumber "1.97.1.11".
- Dio3_Gene wikiPageID "35700328".
- Dio3_Gene wikiPageRevisionID "539970107".
- Dio3_Gene arm "q".
- Dio3_Gene band "32".
- Dio3_Gene chromosome "14".
- Dio3_Gene ecNumber "1.97".
- Dio3_Gene ecnumber "1.97".
- Dio3_Gene entrezgene "1735".
- Dio3_Gene goCode "4800".
- Dio3_Gene hasPhotoCollection Dio3_Gene.
- Dio3_Gene hgncid "2885".
- Dio3_Gene iubmbEcNumber "1".
- Dio3_Gene iupharId "yes".
- Dio3_Gene name "Type III iodothyronine deiodinase".
- Dio3_Gene omim "601038".
- Dio3_Gene refseq "NM_001362".
- Dio3_Gene symbol "DIO3".
- Dio3_Gene uniprot "P55073".
- Dio3_Gene subject Category:Developmental_genes_and_proteins.
- Dio3_Gene subject Category:Genes_on_chromosome_14.
- Dio3_Gene type Biomolecule.
- Dio3_Gene type Enzyme.
- Dio3_Gene type BiologicalObject.
- Dio3_Gene comment "The Dio3 gene codes for type 3 iodothyronine deiodinase (D3), an enzyme that inactivates thyroid hormones and is highly expressed throughout fetal development, peaking early and decreasing towards the end of gestation. Part of the Dlk1-Dio3 imprinting control region, this gene is one involved in the epigenetic process that causes a subset of genes to be regulated based on their parental origin (see Genomic Imprinting).".
- Dio3_Gene label "Dio3 Gene".
- Dio3_Gene sameAs m.0jt4jmv.
- Dio3_Gene sameAs Q5278775.
- Dio3_Gene sameAs Q5278775.
- Dio3_Gene wasDerivedFrom Dio3_Gene?oldid=539970107.
- Dio3_Gene isPrimaryTopicOf Dio3_Gene.
- Dio3_Gene name "Type III iodothyronine deiodinase".