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- Diphenoxylate abstract "Diphenoxylate (R-1132) is an opioid agonist used for the treatment of diarrhea that acts by slowing intestinal contractions and peristalsis allowing the body to consolidate intestinal contents and prolong transit time, thus allowing the intestines to draw moisture out of them at a normal or higher rate and therefore stop the formation of loose and liquid stools. It is the main active ingredient in the anti-peristaltic medication Lomotil, which also contains atropine as noted below.Diphenoxylate is the prototype of a small subfamily of opioids including difenoxin (diphenoxylic acid) (an active metabolite of diphenoxylate produced in the human body) and loperamide (which unlike the other two work exclusively in the intestines because it only crosses the blood–brain barrier in very small amounts). It was discovered at Janssen Pharmaceutica in 1956. It is a congener to the narcotic pethidine of which the common brand names are Dolantin and Demerol amongst others. Other somewhat more distant relatives include alphaprodine (Nisentil) and piritramide (Dipidolor).".
- Diphenoxylate atcPrefix "A07".
- Diphenoxylate atcSuffix "DA01".
- Diphenoxylate casNumber "915-30-0".
- Diphenoxylate chEBI "4639".
- Diphenoxylate drugbank "DB01081".
- Diphenoxylate fdaUniiCode "73312P173G".
- Diphenoxylate iupacName "ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate".
- Diphenoxylate pubchem "13505".
- Diphenoxylate thumbnail Diphenoxylat.svg?width=300.
- Diphenoxylate wikiPageID "1776481".
- Diphenoxylate wikiPageRevisionID "577474587".
- Diphenoxylate atcPrefix "A07".
- Diphenoxylate atcSuffix "DA01".
- Diphenoxylate c "30".
- Diphenoxylate casNumber "915".
- Diphenoxylate chebi "4639".
- Diphenoxylate chembl "1201294".
- Diphenoxylate chemspiderid "12919".
- Diphenoxylate drugbank "DB01081".
- Diphenoxylate eliminationHalfLife "50400.0".
- Diphenoxylate h "32".
- Diphenoxylate hasPhotoCollection Diphenoxylate.
- Diphenoxylate inchi "1".
- Diphenoxylate inchikey "HYPPXZBJBPSRLK-UHFFFAOYAG".
- Diphenoxylate iupacName "ethyl 1--4-phenylpiperidine-4-carboxylate".
- Diphenoxylate kegg "D07861".
- Diphenoxylate legalAu "S8".
- Diphenoxylate legalUk "Class A".
- Diphenoxylate legalUs "Schedule II".
- Diphenoxylate molecularWeight "452.587".
- Diphenoxylate n "2".
- Diphenoxylate o "2".
- Diphenoxylate proteinBound "74".
- Diphenoxylate pubchem "13505".
- Diphenoxylate routesOfAdministration "Oral".
- Diphenoxylate smiles "N#CCCCN4CCCCC4".
- Diphenoxylate stdinchi "1".
- Diphenoxylate stdinchikey "HYPPXZBJBPSRLK-UHFFFAOYSA-N".
- Diphenoxylate unii "73312".
- Diphenoxylate verifiedfields "changed".
- Diphenoxylate verifiedrevid "460791888".
- Diphenoxylate subject Category:Antidiarrhoeals.
- Diphenoxylate subject Category:Belgian_inventions.
- Diphenoxylate subject Category:Janssen_Pharmaceutica.
- Diphenoxylate subject Category:Mu-opioid_agonists.
- Diphenoxylate subject Category:Nitriles.
- Diphenoxylate subject Category:Piperidines.
- Diphenoxylate subject Category:Synthetic_opioids.
- Diphenoxylate type Abstraction100002137.
- Diphenoxylate type Chemical114806838.
- Diphenoxylate type Compound114818238.
- Diphenoxylate type Material114580897.
- Diphenoxylate type Matter100020827.
- Diphenoxylate type Nitrile114827346.
- Diphenoxylate type Nitriles.
- Diphenoxylate type OrganicCompound114727670.
- Diphenoxylate type Part113809207.
- Diphenoxylate type PhysicalEntity100001930.
- Diphenoxylate type Relation100031921.
- Diphenoxylate type Substance100019613.
- Diphenoxylate type Drug.
- Diphenoxylate type DrugProduct.
- Diphenoxylate type FunctionalSubstance.
- Diphenoxylate comment "Diphenoxylate (R-1132) is an opioid agonist used for the treatment of diarrhea that acts by slowing intestinal contractions and peristalsis allowing the body to consolidate intestinal contents and prolong transit time, thus allowing the intestines to draw moisture out of them at a normal or higher rate and therefore stop the formation of loose and liquid stools.".
- Diphenoxylate label "Difenoksylat".
- Diphenoxylate label "Difenoxilato".
- Diphenoxylate label "Diphenoxylat".
- Diphenoxylate label "Diphenoxylate".
- Diphenoxylate sameAs Diphenoxylat.
- Diphenoxylate sameAs Difenoxilato.
- Diphenoxylate sameAs Difenoksylat.
- Diphenoxylate sameAs m.05w0rf.
- Diphenoxylate sameAs Q416431.
- Diphenoxylate sameAs Q416431.
- Diphenoxylate sameAs diphenoxylate.
- Diphenoxylate sameAs DB01081.
- Diphenoxylate sameAs Diphenoxylate.
- Diphenoxylate wasDerivedFrom Diphenoxylate?oldid=577474587.
- Diphenoxylate depiction Diphenoxylat.svg.
- Diphenoxylate isPrimaryTopicOf Diphenoxylate.