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- Diphthamide abstract "Diphthamide is a modified histidine amino acid found in eukaryotic elongation factor 2 (eEF-2). It is usually found at position H715 in mammalian eEF2 (H699 in yeast). This residue is modified by the protein encoded by the OVCA1 gene (homolog of DPH1 in mice). DPH1 knockout mice are inviable while heterozygotes develop diverse types of carcinomas and sarcomas. In humans, OVCA1 is frequently found mutated in ovarian cancer. Loss of heterozygosity has taken place in 50% of benign tumours, and 90% of end-stage ovarian tumours.It is ADP-ribosylated by diphtheria toxin, hence the name, which renders the elongation factor inactive.".
- Diphthamide iupacName "2-Amino-3-[2-(3-carbamoyl-3-trimethylammonio-propyl)-3H-imidazol-4-yl]propanoate".
- Diphthamide thumbnail Diphthamide.png?width=300.
- Diphthamide wikiPageID "11698208".
- Diphthamide wikiPageRevisionID "551513061".
- Diphthamide hasPhotoCollection Diphthamide.
- Diphthamide imagefile "diphthamide.png".
- Diphthamide imagesize "200".
- Diphthamide iupacname "2".
- Diphthamide verifiedrevid "428011922".
- Diphthamide subject Category:Amino_acids.
- Diphthamide subject Category:Imidazoles.
- Diphthamide subject Category:Posttranslational_modification.
- Diphthamide subject Category:Quaternary_ammonium_compounds.
- Diphthamide type Abstraction100002137.
- Diphthamide type AminoAcid114601829.
- Diphthamide type AminoAcids.
- Diphthamide type Base114618253.
- Diphthamide type Chemical114806838.
- Diphthamide type Compound114818238.
- Diphthamide type Imidazole114916670.
- Diphthamide type Imidazoles.
- Diphthamide type Material114580897.
- Diphthamide type Matter100020827.
- Diphthamide type OrganicCompound114727670.
- Diphthamide type Part113809207.
- Diphthamide type PhysicalEntity100001930.
- Diphthamide type QuaternaryAmmoniumCompound114691231.
- Diphthamide type QuaternaryAmmoniumCompounds.
- Diphthamide type Relation100031921.
- Diphthamide type Substance100019613.
- Diphthamide type ChemicalCompound.
- Diphthamide type ChemicalSubstance.
- Diphthamide type ChemicalSubstanceType.
- Diphthamide type ChemicalObject.
- Diphthamide type Thing.
- Diphthamide comment "Diphthamide is a modified histidine amino acid found in eukaryotic elongation factor 2 (eEF-2). It is usually found at position H715 in mammalian eEF2 (H699 in yeast). This residue is modified by the protein encoded by the OVCA1 gene (homolog of DPH1 in mice). DPH1 knockout mice are inviable while heterozygotes develop diverse types of carcinomas and sarcomas. In humans, OVCA1 is frequently found mutated in ovarian cancer.".
- Diphthamide label "Diftamide".
- Diphthamide label "Diphthamid".
- Diphthamide label "Diphthamide".
- Diphthamide label "Дифтамид".
- Diphthamide sameAs Diphthamid.
- Diphthamide sameAs Diftamide.
- Diphthamide sameAs m.02rpc3r.
- Diphthamide sameAs Q61344.
- Diphthamide sameAs Q61344.
- Diphthamide sameAs DB03223.
- Diphthamide sameAs Diphthamide.
- Diphthamide wasDerivedFrom Diphthamide?oldid=551513061.
- Diphthamide depiction Diphthamide.png.
- Diphthamide isPrimaryTopicOf Diphthamide.
