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- Diprenorphine abstract "Diprenorphine (diprenorfin, Revivon, M5050) is an opioid antagonist used to reverse the effects of the super-potent opioid analgesics such as etorphine and carfentanil that are used for tranquilizing large animals in veterinary medicine.Diprenorphine is the strongest opiate antagonist that is commercially available (some 100 times more potent as an antagonist than nalorphine), and is used for reversing the effects of very strong opioids for which the binding affinity is so high that naloxone does not effectively or reliably reverse the narcotic effects. These super-potent opioids, with the single exception of buprenorphine, are not used in humans because the dose for a human is so small that it would be difficult to measure properly, so there is an excessive risk of overdose leading to fatal respiratory depression. However conventional opioid derivatives are not strong enough to rapidly tranquilize large animals such as elephants and rhinos, so drugs such as etorphine or carfentanil are available for this purpose. Diprenorphine is considered the specific antagonist for etorphine and carfentanil, and is normally used to remobilise animals once veterinary procedures have been completed,. Because diprenorphine also has some agonistic properties of its own, it should not be used on humans in the event that they are accidentally exposed to etorphine or carfentanil. Naloxone or naltrexone are the preferred human antagonists.In theory, diprenorphine could also be used as an antidote for treating overdose of certain opioid derivatives which are used in humans, such as buprenorphine, for which the binding affinity is so high that naloxone does not reliably reverse the narcotic effects. However, diprenorphine is not generally available in hospitals; instead a vial of diprenorphine is supplied with etorphine or carfentanil specifically for reversing the effects of these drugs, so use of diprenorphine for treating e.g. a buprenorphine overdose is not carried out in practice, although it would work in theory.".
- Diprenorphine atcPrefix "V03".
- Diprenorphine atcSuffix "AB92".
- Diprenorphine casNumber "14357-78-9".
- Diprenorphine drugbank "DB01548".
- Diprenorphine fdaUniiCode "1F0L5N25ZZ".
- Diprenorphine iupacName "(5α,7α)-17-(Cyclopropylmethyl)- 4,5-epoxy- 18,19-dihydro- 3-hydroxy- 6-methoxy- α,α-dimethyl- 6,14-ethenomorphinan- 7-methanol".
- Diprenorphine pubchem "443408".
- Diprenorphine thumbnail Diprenorphine.svg?width=300.
- Diprenorphine wikiPageID "10977211".
- Diprenorphine wikiPageRevisionID "552546555".
- Diprenorphine atcPrefix "V03".
- Diprenorphine atcSuffix "AB92".
- Diprenorphine atcvet "yes".
- Diprenorphine c "26".
- Diprenorphine casNumber "14357".
- Diprenorphine chembl "281786".
- Diprenorphine chemspiderid "391634".
- Diprenorphine drugbank "DB01548".
- Diprenorphine h "35".
- Diprenorphine hasPhotoCollection Diprenorphine.
- Diprenorphine inchi "1".
- Diprenorphine inchikey "OIJXLIIMXHRJJH-KNLIIKEYBV".
- Diprenorphine iupacName "-17".
- Diprenorphine iupharLigand "1617".
- Diprenorphine kegg "D07863".
- Diprenorphine molecularWeight "425.56".
- Diprenorphine n "1".
- Diprenorphine o "4".
- Diprenorphine pubchem "443408".
- Diprenorphine smiles "CCO".
- Diprenorphine stdinchi "1".
- Diprenorphine stdinchikey "OIJXLIIMXHRJJH-KNLIIKEYSA-N".
- Diprenorphine unii "1".
- Diprenorphine verifiedfields "changed".
- Diprenorphine verifiedrevid "460793422".
- Diprenorphine width "180".
- Diprenorphine subject Category:Alcohols.
- Diprenorphine subject Category:Ethers.
- Diprenorphine subject Category:Morphinans.
- Diprenorphine subject Category:Opioid_antagonists.
- Diprenorphine subject Category:Phenols.
- Diprenorphine subject Category:Semisynthetic_opioids.
- Diprenorphine type Abstraction100002137.
- Diprenorphine type Agent114778436.
- Diprenorphine type Alcohol107884567.
- Diprenorphine type Alcohols.
- Diprenorphine type Beverage107881800.
- Diprenorphine type CausalAgent100007347.
- Diprenorphine type Chemical114806838.
- Diprenorphine type Compound114818238.
- Diprenorphine type Drug103247620.
- Diprenorphine type DrugOfAbuse103248958.
- Diprenorphine type Element114840755.
- Diprenorphine type Ethers.
- Diprenorphine type Fluid114939900.
- Diprenorphine type Food100021265.
- Diprenorphine type Liquid114940386.
- Diprenorphine type Material114580897.
- Diprenorphine type Matter100020827.
- Diprenorphine type OrganicCompound114727670.
- Diprenorphine type Part113809207.
- Diprenorphine type Phenol114989545.
- Diprenorphine type Phenols.
- Diprenorphine type PhysicalEntity100001930.
- Diprenorphine type Quintessence114847103.
- Diprenorphine type Relation100031921.
- Diprenorphine type Substance100019613.
- Diprenorphine type Substance100020090.
- Diprenorphine type Drug.
- Diprenorphine type DrugProduct.
- Diprenorphine type FunctionalSubstance.
- Diprenorphine comment "Diprenorphine (diprenorfin, Revivon, M5050) is an opioid antagonist used to reverse the effects of the super-potent opioid analgesics such as etorphine and carfentanil that are used for tranquilizing large animals in veterinary medicine.Diprenorphine is the strongest opiate antagonist that is commercially available (some 100 times more potent as an antagonist than nalorphine), and is used for reversing the effects of very strong opioids for which the binding affinity is so high that naloxone does not effectively or reliably reverse the narcotic effects. ".
- Diprenorphine label "Diprenorphin".
- Diprenorphine label "Diprenorphine".
- Diprenorphine sameAs Diprenorphin.
- Diprenorphine sameAs m.02qwy_c.
- Diprenorphine sameAs Q424009.
- Diprenorphine sameAs Q424009.
- Diprenorphine sameAs DB01548.
- Diprenorphine sameAs Diprenorphine.
- Diprenorphine wasDerivedFrom Diprenorphine?oldid=552546555.
- Diprenorphine depiction Diprenorphine.svg.
- Diprenorphine isPrimaryTopicOf Diprenorphine.
