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- Direct_DNA_damage abstract "Direct DNA damage can occur when DNA directly absorbs the UV-B-photon. UVB light causes thymine base pairs next to each other in genetic sequences to bond together into pyrimidine dimers, a disruption in the strand, which reproductive enzymes cannot copy. It causes sunburn and it triggers the production of melanin.Other names for the "direct DNA damage" are:thymine dimers pyrimidine dimersCyclobutane Pyrimidine Dimers (CPDs). UV-endonuclease-sensitive-sites (ESS)Due to the excellent photochemical properties of DNA, this nature-made molecule is damaged only by a tiny fraction of the absorbed photons. DNA transforms more than 99.9% of the photons into harmless heat (But the damage from the remaining < 0.1% of the photons is still enough to cause sunburn). The transformation of excitation energy into harmless heat occurs via a photochemical process called internal conversion. In DNA, this internal conversion is extremely fast—and therefore efficient. This ultrafast (subpicosecond) internal conversion is an extremely powerful photoprotection provided by single nucleotides. However, the Ground-State Recovery is much slower (picoseconds) in G·C−DNA duplexes and hairpins. It is presumed to be even slower for double-stranded DNA in conditions of the nucleus.The absorption spectrum of DNA shows a strong absorption for UVB-radiation and a much lower absorption for UVA-radiation. Since the action spectrum of sunburn is identical to the absorption spectrum of DNA, it is generally accepted that the direct DNA damages are the cause of sunburn.While the human body reacts to direct DNA damages with a painful warning signal, no such warning signal is generated from indirect DNA damage.".
- Direct_DNA_damage thumbnail Direct_DNA_damage.png?width=300.
- Direct_DNA_damage wikiPageID "15755697".
- Direct_DNA_damage wikiPageRevisionID "594001028".
- Direct_DNA_damage hasPhotoCollection Direct_DNA_damage.
- Direct_DNA_damage subject Category:Photochemistry.
- Direct_DNA_damage subject Category:Skin_conditions_resulting_from_physical_factors.
- Direct_DNA_damage subject Category:Skin_physiology.
- Direct_DNA_damage subject Category:Sun_tanning.
- Direct_DNA_damage type Abstraction100002137.
- Direct_DNA_damage type Attribute100024264.
- Direct_DNA_damage type Condition113920835.
- Direct_DNA_damage type SkinConditionsResultingFromPhysicalFactors.
- Direct_DNA_damage type State100024720.
- Direct_DNA_damage comment "Direct DNA damage can occur when DNA directly absorbs the UV-B-photon. UVB light causes thymine base pairs next to each other in genetic sequences to bond together into pyrimidine dimers, a disruption in the strand, which reproductive enzymes cannot copy. It causes sunburn and it triggers the production of melanin.Other names for the "direct DNA damage" are:thymine dimers pyrimidine dimersCyclobutane Pyrimidine Dimers (CPDs).".
- Direct_DNA_damage label "Direct DNA damage".
- Direct_DNA_damage sameAs m.03nsfp6.
- Direct_DNA_damage sameAs Q4897368.
- Direct_DNA_damage sameAs Q4897368.
- Direct_DNA_damage sameAs Direct_DNA_damage.
- Direct_DNA_damage wasDerivedFrom Direct_DNA_damage?oldid=594001028.
- Direct_DNA_damage depiction Direct_DNA_damage.png.
- Direct_DNA_damage isPrimaryTopicOf Direct_DNA_damage.
