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- Dirithromycin abstract "Dirithromycin is a macrolide glycopeptide antibiotic.Dirithromycin (Dynabac) is a more lipid-soluble prodrug derivative of 9S-erythromycyclamine prepared by condensation of the latter with 2-(2-methoxyethoxy)acetaldehyde. The 9N, 11O-oxazine ring thus formed is a hemi-aminal that is unstable under both acidic and alkaline aqueous conditions and undergoes spontaneous hydrolysis to form erythromycyclamine. Erythromycyclamine is a semisynthetic derivative of erythromycin in which the 9-ketogroup of the erythronolide ring has been converted to an amino group. Erythromycyclamine retains the antibacterial properties of erythromycin oral administration. The prodrug, dirithromycin, is provided as enteric coated tablets to protect it from acid catalyzed hydrolysis in the stomach.Orally administered dirithromycin is absorbed rapidly into the plasma, largely from the small intestine. Spontaneous hydrolysis to erythromycyclamine occurs in the plasma. Oral bioavailability is estimated to be about 10%, but food does not affect absorption of the prodrug.".
- Dirithromycin atcPrefix "J01".
- Dirithromycin atcSuffix "FA13".
- Dirithromycin bioavailability "10.0".
- Dirithromycin casNumber "62013-04-1".
- Dirithromycin chEBI "474014".
- Dirithromycin drugbank "DB00954".
- Dirithromycin fdaUniiCode "1801D76STL".
- Dirithromycin iupacName "(2R,3R,6R,7S,8S,9R,10R,12R,13S,15R,17S)-9-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-3-ethyl-2,10-dihydroxy-7-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-15-[(2-methoxyethoxy)methyl]-2,6,8,10,12,17-hexamethyl-4,16-dioxa-14-azabicyclo[11.3.1]heptadecan-5-one".
- Dirithromycin pubchem "6917067".
- Dirithromycin thumbnail Dirithromycin.svg?width=300.
- Dirithromycin wikiPageID "6050838".
- Dirithromycin wikiPageRevisionID "586346039".
- Dirithromycin atcPrefix "J01".
- Dirithromycin atcSuffix "FA13".
- Dirithromycin bioavailability "10.0".
- Dirithromycin c "42".
- Dirithromycin casNumber "62013".
- Dirithromycin chebi "474014".
- Dirithromycin chembl "1200505".
- Dirithromycin chemspiderid "5292341".
- Dirithromycin drugbank "DB00954".
- Dirithromycin h "78".
- Dirithromycin hasPhotoCollection Dirithromycin.
- Dirithromycin inchi "1".
- Dirithromycin inchikey "WLOHNSSYAXHWNR-NXPDYKKBBI".
- Dirithromycin iupacName "-9".
- Dirithromycin kegg "D03865".
- Dirithromycin licenceUs "Clarithromycin".
- Dirithromycin medlineplus "a604026".
- Dirithromycin metabolism "5400.0".
- Dirithromycin molecularWeight "835.074".
- Dirithromycin n "2".
- Dirithromycin o "14".
- Dirithromycin pregnancyCategory "B".
- Dirithromycin proteinBound "15".
- Dirithromycin pubchem "6917067".
- Dirithromycin routesOfAdministration "Oral".
- Dirithromycin smiles "O=C4O[C@@H]CC".
- Dirithromycin stdinchi "1".
- Dirithromycin stdinchikey "WLOHNSSYAXHWNR-NXPDYKKBSA-N".
- Dirithromycin tradename "Dynabac".
- Dirithromycin unii "1801".
- Dirithromycin verifiedfields "changed".
- Dirithromycin verifiedrevid "460794200".
- Dirithromycin width "280".
- Dirithromycin subject Category:Macrolide_antibiotics.
- Dirithromycin subject Category:Prodrugs.
- Dirithromycin type Agent114778436.
- Dirithromycin type Antibacterial102716205.
- Dirithromycin type Antibiotic102716866.
- Dirithromycin type CausalAgent100007347.
- Dirithromycin type Drug103247620.
- Dirithromycin type MacrolideAntibiotics.
- Dirithromycin type Matter100020827.
- Dirithromycin type Medicine103740161.
- Dirithromycin type PhysicalEntity100001930.
- Dirithromycin type Substance100020090.
- Dirithromycin type Drug.
- Dirithromycin type DrugProduct.
- Dirithromycin type FunctionalSubstance.
- Dirithromycin comment "Dirithromycin is a macrolide glycopeptide antibiotic.Dirithromycin (Dynabac) is a more lipid-soluble prodrug derivative of 9S-erythromycyclamine prepared by condensation of the latter with 2-(2-methoxyethoxy)acetaldehyde. The 9N, 11O-oxazine ring thus formed is a hemi-aminal that is unstable under both acidic and alkaline aqueous conditions and undergoes spontaneous hydrolysis to form erythromycyclamine.".
- Dirithromycin label "Dirithromycin".
- Dirithromycin label "Dirithromycine".
- Dirithromycin label "Diritromicina".
- Dirithromycin label "Диритромицин".
- Dirithromycin sameAs Dirithromycine.
- Dirithromycin sameAs Diritromicina.
- Dirithromycin sameAs m.0fmld1.
- Dirithromycin sameAs Q1989071.
- Dirithromycin sameAs Q1989071.
- Dirithromycin sameAs DB00954.
- Dirithromycin sameAs Dirithromycin.
- Dirithromycin wasDerivedFrom Dirithromycin?oldid=586346039.
- Dirithromycin depiction Dirithromycin.svg.
- Dirithromycin isPrimaryTopicOf Dirithromycin.
