Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Docetaxel> ?p ?o. }
- Docetaxel abstract "Docetaxel (as generic or under the trade name Taxotere or Docefrez) is a clinically well-established anti-mitotic chemotherapy medication that works by interfering with cell division. Docetaxel is approved by the FDA for treatment of locally advanced or metastatic breast cancer, head and neck cancer, gastric cancer, hormone-refractory prostate cancer and non small-cell lung cancer. Docetaxel can be used as a single agent or in combination with other chemotherapeutic drugs as indicated depending on specific cancer type and stage.Docetaxel is a member of the taxane drug class, which also includes the chemotherapeutic medication paclitaxel. Although docetaxel remains twice as potent as paclitaxel (due to docetaxel’s effect on the centrosome of the mitotic spindle), the two taxanes have been observed to have comparable efficacy. Several recent articles have found "no evidence that regimens containing docetaxel yield greater benefits than those including paclitaxel." While efficacy between the two agents has been observed to be equivalent, paclitaxel may cause fewer side effects. Additionally, it has been noted that docetaxel is prone to cellular drug resistance via a variety of different mechanisms.The optimal dose scheduling of taxanes remains unconfirmed, but most studies find significant mortality benefit following either a three-week or a one-week administration schedule. While a 2010 article in Current Clinical Pharmacology states, "weekly administration has emerged as the optimal schedule," the official docetaxel package insert recommends administration every three weeks. Important toxicities to note include neutropenia, febrile neutropenia and neurosensory disturbances. Such toxicities have been well documented in Phase II and Phase III clinical trials and can be anticipated and subsequently managed.Docetaxel is marketed worldwide under the name Taxotere by Sanofi-Aventis as well as Docefrez by Sun Pharma Global. Annual sales of Taxotere in 2010 were Euro 2.122 billion ($US 3.1 billion). The patent expired in 2010.[citation needed]Clinicians sometimes use the abbreviation "TXT" for docetaxel, although (like many medical abbreviations) it is not a unique identifier.".
- Docetaxel atcPrefix "L01".
- Docetaxel atcSuffix "CD02".
- Docetaxel casNumber "114977-28-5".
- Docetaxel chEBI "4672".
- Docetaxel drugbank "DB01248".
- Docetaxel fdaUniiCode "699121PHCA".
- Docetaxel iupacName "1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}".
- Docetaxel pubchem "148124".
- Docetaxel thumbnail Docetaxel.svg?width=300.
- Docetaxel wikiPageExternalLink taxotere.html.
- Docetaxel wikiPageExternalLink www.taxotere.com.
- Docetaxel wikiPageID "2235616".
- Docetaxel wikiPageRevisionID "605588689".
- Docetaxel atcPrefix "L01".
- Docetaxel atcSuffix "CD02".
- Docetaxel bioavailability "NA".
- Docetaxel c "43".
- Docetaxel casNumber "114977".
- Docetaxel chebi "4672".
- Docetaxel chembl "92".
- Docetaxel chemspiderid "130581".
- Docetaxel drugbank "DB01248".
- Docetaxel eliminationHalfLife "309600.0".
- Docetaxel excretion Bile.
- Docetaxel h "53".
- Docetaxel hasPhotoCollection Docetaxel.
- Docetaxel image "Docetaxel3D.png".
- Docetaxel inchi "1".
- Docetaxel inchikey "ZDZOTLJHXYCWBA-VCVYQ WHSBS".
- Docetaxel iupacName "17".
- Docetaxel kegg "D07866".
- Docetaxel legalStatus "Rx-only".
- Docetaxel medlineplus "a696031".
- Docetaxel metabolism Liver.
- Docetaxel molecularWeight "807.879".
- Docetaxel n "1".
- Docetaxel o "14".
- Docetaxel pregnancyUs "D".
- Docetaxel proteinBound ">98%".
- Docetaxel pubchem "148124".
- Docetaxel routesOfAdministration Intravenous_therapy.
- Docetaxel smiles "O=CN[C@@H][C@@H]CO[C@@H]4C/C".
- Docetaxel stdinchi "1".
- Docetaxel stdinchikey "ZDZOTLJHXYCWBA-VCVYQWHSSA-N".
- Docetaxel tradename "Taxotere".
- Docetaxel unii "699121".
- Docetaxel verifiedfields "changed".
- Docetaxel verifiedrevid "461754129".
- Docetaxel watchedfields "changed".
- Docetaxel width "250".
- Docetaxel subject Category:Acetate_esters.
- Docetaxel subject Category:Alkaloids.
- Docetaxel subject Category:Benzoates.
- Docetaxel subject Category:Carbamates.
- Docetaxel subject Category:Microtubule_inhibitors.
- Docetaxel subject Category:Mitotic_inhibitors.
- Docetaxel type Abstraction100002137.
- Docetaxel type AcetateEsters.
- Docetaxel type Alkaloid114712692.
- Docetaxel type Alkaloids.
- Docetaxel type Benzoate114775067.
- Docetaxel type Benzoates.
- Docetaxel type Carbamate114792281.
- Docetaxel type Carbamates.
- Docetaxel type Chemical114806838.
- Docetaxel type Compound114818238.
- Docetaxel type Ester114850483.
- Docetaxel type Material114580897.
- Docetaxel type Matter100020827.
- Docetaxel type OrganicCompound114727670.
- Docetaxel type Part113809207.
- Docetaxel type PhysicalEntity100001930.
- Docetaxel type Relation100031921.
- Docetaxel type Salt115010703.
- Docetaxel type Substance100019613.
- Docetaxel type Drug.
- Docetaxel type DrugProduct.
- Docetaxel type FunctionalSubstance.
- Docetaxel comment "Docetaxel (as generic or under the trade name Taxotere or Docefrez) is a clinically well-established anti-mitotic chemotherapy medication that works by interfering with cell division. Docetaxel is approved by the FDA for treatment of locally advanced or metastatic breast cancer, head and neck cancer, gastric cancer, hormone-refractory prostate cancer and non small-cell lung cancer.".
- Docetaxel label "Docetaksel".
- Docetaxel label "Docetaxel".
- Docetaxel label "Docetaxel".
- Docetaxel label "Docetaxel".
- Docetaxel label "Docetaxel".
- Docetaxel label "Docetaxel".
- Docetaxel label "Docetaxel".
- Docetaxel label "Docétaxel".
- Docetaxel label "Доцетаксел".
- Docetaxel label "ドセタキセル".
- Docetaxel label "歐洲紫杉醇".
- Docetaxel sameAs Docetaxel.
- Docetaxel sameAs Docetaxel.
- Docetaxel sameAs Docetaxel.
- Docetaxel sameAs Docétaxel.
- Docetaxel sameAs Docetaxel.
- Docetaxel sameAs ドセタキセル.
- Docetaxel sameAs Docetaxel.
- Docetaxel sameAs Docetaksel.
- Docetaxel sameAs Docetaxel.