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- E2F2 abstract "Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.".
- E2F2 entrezgene "1870".
- E2F2 wikiPageID "14170793".
- E2F2 wikiPageRevisionID "591125808".
- E2F2 hasPhotoCollection E2F2.
- E2F2 requireManualInspection "no".
- E2F2 summaryText "The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins , a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.".
- E2F2 updateCitations "yes".
- E2F2 updatePage "yes".
- E2F2 updateProteinBox "yes".
- E2F2 updateSummary "yes".
- E2F2 subject Category:Transcription_factors.
- E2F2 type Biomolecule.
- E2F2 type Protein.
- E2F2 type BiologicalObject.
- E2F2 comment "Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family.".
- E2F2 label "E2F2".
- E2F2 label "E2F2".
- E2F2 sameAs E2F2.
- E2F2 sameAs m.03cwrk3.
- E2F2 sameAs Q5322374.
- E2F2 sameAs Q5322374.
- E2F2 wasDerivedFrom E2F2?oldid=591125808.
- E2F2 isPrimaryTopicOf E2F2.