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- E2F3 abstract "Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.".
- E2F3 entrezgene "1871".
- E2F3 wikiPageID "14169669".
- E2F3 wikiPageRevisionID "591125849".
- E2F3 hasPhotoCollection E2F3.
- E2F3 requireManualInspection "no".
- E2F3 summaryText "The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins , a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.".
- E2F3 updateCitations "yes".
- E2F3 updatePage "yes".
- E2F3 updateProteinBox "yes".
- E2F3 updateSummary "yes".
- E2F3 subject Category:Transcription_factors.
- E2F3 type Biomolecule.
- E2F3 type Protein.
- E2F3 type BiologicalObject.
- E2F3 comment "Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family.".
- E2F3 label "E2F3".
- E2F3 sameAs m.03cwqny.
- E2F3 sameAs Q5322376.
- E2F3 sameAs Q5322376.
- E2F3 wasDerivedFrom E2F3?oldid=591125849.
- E2F3 isPrimaryTopicOf E2F3.