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- E2F5 abstract "Transcription factor E2F5 is a protein that in humans is encoded by the E2F5 gene.The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.".
- E2F5 entrezgene "1875".
- E2F5 wikiPageID "14794239".
- E2F5 wikiPageRevisionID "591125916".
- E2F5 hasPhotoCollection E2F5.
- E2F5 requireManualInspection "no".
- E2F5 summaryText "The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins , a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.".
- E2F5 updateCitations "yes".
- E2F5 updatePage "yes".
- E2F5 updateProteinBox "yes".
- E2F5 updateSummary "yes".
- E2F5 subject Category:Transcription_factors.
- E2F5 type Biomolecule.
- E2F5 type Protein.
- E2F5 type BiologicalObject.
- E2F5 comment "Transcription factor E2F5 is a protein that in humans is encoded by the E2F5 gene.The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family.".
- E2F5 label "E2F5".
- E2F5 sameAs m.03gy4k1.
- E2F5 sameAs Q5322378.
- E2F5 sameAs Q5322378.
- E2F5 wasDerivedFrom E2F5?oldid=591125916.
- E2F5 isPrimaryTopicOf E2F5.