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- EA-3443 abstract "EA-3443 is a potent and long lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB. The main advantages of EA-3443 were not only increased potency over QNB, but also a significantly improved central to peripheral effects ratio. Anticholinergic drugs produce both incapacitating deliriant effects through action in the brain, and a variety of distinctive physical symptoms such as dry mouth, dilated pupils, blurred vision and hot flushed skin, all of which together comprise the "anticholinergic syndrome" which is generally easy for doctors to diagnose. EA-3443 however is mainly selective for the brain, and when administered in a narrow dose range of around 0.3mg can produce the central effects of confusion, hallucinations and amnesia, but without producing significant physical symptoms, which was predicted to make poisoning with EA-3443 much more difficult to diagnose and treat. However despite these advantages, EA-3443 was never researched to the same extent as QNB or manufactured in bulk, and research into EA-3443 was discontinued along with the rest of the US chemical weapons program in the mid-1970s.".
- EA-3443 casNumber "37830-21-0".
- EA-3443 iupacName "(1-methylpiperidin-4-yl) 2-cyclopentyl-2-hydroxy-2-phenylacetate".
- EA-3443 pubchem "37838".
- EA-3443 thumbnail EA-3443_structure.png?width=300.
- EA-3443 wikiPageID "23249993".
- EA-3443 wikiPageRevisionID "448240463".
- EA-3443 c "19".
- EA-3443 casNumber "37830".
- EA-3443 h "27".
- EA-3443 hasPhotoCollection EA-3443.
- EA-3443 iupacName "2".
- EA-3443 molecularWeight "317.422".
- EA-3443 n "1".
- EA-3443 o "3".
- EA-3443 pubchem "37838".
- EA-3443 smiles "C1CNCCC1OCCc2ccccc2".
- EA-3443 verifiedrevid "424815733".
- EA-3443 watchedfields "changed".
- EA-3443 width "240".
- EA-3443 subject Category:Anticholinergics.
- EA-3443 subject Category:Deliriants.
- EA-3443 subject Category:Incapacitating_agents.
- EA-3443 subject Category:Piperidines.
- EA-3443 type Drug.
- EA-3443 type DrugProduct.
- EA-3443 type FunctionalSubstance.
- EA-3443 comment "EA-3443 is a potent and long lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB. The main advantages of EA-3443 were not only increased potency over QNB, but also a significantly improved central to peripheral effects ratio.".
- EA-3443 label "EA-3443".
- EA-3443 sameAs m.065yk0s.
- EA-3443 sameAs Q5322469.
- EA-3443 sameAs Q5322469.
- EA-3443 wasDerivedFrom EA-3443?oldid=448240463.
- EA-3443 depiction EA-3443_structure.png.
- EA-3443 isPrimaryTopicOf EA-3443.
