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- EIF1 abstract "Eukaryotic translation initiation factor 1 is a protein that in humans is encoded by the EIF1 gene.Mammalian 17-kDa eukaryotic initiation factor, eIF1A (formerly designated eIF-4C), is essential for transfer of the initiator Met-tRNAf (as Met-tRNAf·eIF2·GTP ternary complex) to 40 S ribosomal subunits in the absence of mRNA to form the 40 S preinitiation complex (40 S·Met-tRNAf·eIF2·GTP). Furthermore, eIF1A acts catalytically in this reaction to mediate highly efficient transfer of the Met-tRNAf·eIF2·GTP ternary complex to 40 S ribosomal subunits. The 40 S complex formed is free of eIF1A which indicates that its role in 40 S preinitiation complex formation is not to stabilize the binding of Met-tRNAf to 40 S ribosomes. Additionally, the eIF1A-mediated 40 S initiation complex formed in the presence of AUG codon efficiently joins 60 S ribosomal subunits in an eIF5-dependent reaction to form a functional 80 S initiation complex. Though found in some reports, eIF1A probably plays no role either in the subunit joining reaction or in the generation of ribosomal subunits from 80 S ribosomes. The major function of eIF1A is to mediate the transfer of Met-tRNAf to 40 S ribosomal subunits to form the 40 S preinitiation complex.".
- EIF1 entrezgene "10209".
- EIF1 wikiPageExternalLink nrmicro1558_BX1.html.
- EIF1 wikiPageID "15182073".
- EIF1 wikiPageRevisionID "591165387".
- EIF1 hasPhotoCollection EIF1.
- EIF1 requireManualInspection "no".
- EIF1 updateCitations "yes".
- EIF1 updatePage "yes".
- EIF1 updateProteinBox "yes".
- EIF1 updateSummary "yes".
- EIF1 type Biomolecule.
- EIF1 type Protein.
- EIF1 type BiologicalObject.
- EIF1 comment "Eukaryotic translation initiation factor 1 is a protein that in humans is encoded by the EIF1 gene.Mammalian 17-kDa eukaryotic initiation factor, eIF1A (formerly designated eIF-4C), is essential for transfer of the initiator Met-tRNAf (as Met-tRNAf·eIF2·GTP ternary complex) to 40 S ribosomal subunits in the absence of mRNA to form the 40 S preinitiation complex (40 S·Met-tRNAf·eIF2·GTP).".
- EIF1 label "EIF1".
- EIF1 label "真核起始因子1".
- EIF1 sameAs m.03hl37p.
- EIF1 sameAs Q5323135.
- EIF1 sameAs Q5323135.
- EIF1 wasDerivedFrom EIF1?oldid=591165387.
- EIF1 isPrimaryTopicOf EIF1.